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Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer

Authors
 Ho-Taek Song  ;  Ngoc Ha Hoang  ;  Jeong Min Yun  ;  Young Jin Park  ;  Eun Hye Song  ;  Eun Seong Lee  ;  Yu Seok Youn  ;  Kyung Taek Oh 
Citation
 COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.144 : 73-80, 2016 
Journal Title
 COLLOIDS AND SURFACES B-BIOINTERFACES 
ISSN
 0927-7765 
Issue Date
2016
MeSH
Animals ; Breast Neoplasms/drug therapy* ; Breast Neoplasms/pathology* ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Delivery Systems ; Feasibility Studies ; Female ; Humans ; Kinetics ; Luminescent Measurements ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Neoplasm Metastasis ; Polyesters/chemistry* ; Polyethylene Glycols/chemistry*
Keywords
Animal imaging ; Biocompatibility ; Metastasis ; Nanomedicine ; Tri-block copolymer
Abstract
We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S0927776516302594
DOI
10.1016/j.colsurfb.2016.04.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Song, Eun Hye(송은혜)
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151622
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