Cited 19 times in
An implication of hypertriglyceridemia in the progression of diabetic nephorpathy in metabolically obese, normal weightpatients with type 2 diabetes mellitus in Korea
DC Field | Value | Language |
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dc.contributor.author | 안철우 | - |
dc.date.accessioned | 2017-10-26T06:54:26Z | - |
dc.date.available | 2017-10-26T06:54:26Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151474 | - |
dc.description.abstract | This study was undertaken to investigate diverse risk factors affecting the progression of diabetic nephropathy (DN) by observing the changes of 24 h urinary albumin excretion (24 h UAE) in 90 abdominally obese, normal weight, type 2 diabetic patients with normo- or micro-albuminuria. Patients were divided into three groups according to the 24h UAE; normo-, micro-, and macro-albuminuria group. After 4 years of follow-up, patients were divided into either progression or non-progression group according to the changes of 24 h UAE. About 37% of the normo-albuminuria group and 18% of the micro-albumiuria group were classified into the progression group. The initial serum creatinine levels and the initial and follow-up post-prandial plasma glucose levels were significantly higher in the progression group than in the non-progression group. Most remarkably, the initial and follow-up serum triglyceride (TG) levels (190 +/- 132 versus 132 +/- 49 mg/dl and 191 +/- 124 versus 133 +/- 41 mg/dl, P < 0.01 in both) were significantly higher in the progression group than in the non-progression group, suggesting hypertriglyceridemia might be included in the progression factors of DN. The increases in 24-hour UAE were positively associated with the initial and follow-up post-prandial plasma glucose levels (P < 0.05 in both), the initial and follow-up serum creatinine levels (P < 0.05 in both), and the initial serum TG levels (P < 0.05). Whereas, insulin users or patients with retinopathy at follow-up (P < 0.05 in both) showed more rapid progression of albuminuria, ACE inhibitors or acarbose (P < 0.05 in both) use turned out to protect against it. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Albuminuria | - |
dc.subject.MESH | Basal Metabolism* | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | DiabetesComplications/physiopathology | - |
dc.subject.MESH | DiabetesMellitus,Type2/complications | - |
dc.subject.MESH | DiabetesMellitus,Type2/physiopathology* | - |
dc.subject.MESH | DiabeticNephropathies/physiopathology* | - |
dc.subject.MESH | DiabeticNephropathies/urine | - |
dc.subject.MESH | DiseaseProgression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertriglyceridemia/complications | - |
dc.subject.MESH | Hypertriglyceridemia/epidemiology* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/complications | - |
dc.subject.MESH | Obesity/physiopathology | - |
dc.subject.MESH | Reference Values | - |
dc.title | An implication of hypertriglyceridemia in the progression of diabetic nephorpathy in metabolically obese, normal weightpatients with type 2 diabetes mellitus in Korea | - |
dc.type | Article | - |
dc.publisher.location | Ireland | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | D.M. Kim | - |
dc.contributor.googleauthor | J.S. Park | - |
dc.contributor.googleauthor | B.S. Cha | - |
dc.contributor.googleauthor | S.K. Lim | - |
dc.contributor.googleauthor | K.R. Kim | - |
dc.contributor.googleauthor | H.C. Lee | - |
dc.contributor.googleauthor | K.B. Huh | - |
dc.identifier.doi | 10.1016/j.diabres.2004.07.011 | - |
dc.contributor.localId | A02270 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 15563971 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S016882270400213X | - |
dc.subject.keyword | Diabetic nephropathy | - |
dc.subject.keyword | Albuminuria | - |
dc.subject.keyword | Triglyceride | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.citation.volume | 66 | - |
dc.citation.number | Suppl. 1 | - |
dc.citation.startPage | S169 | - |
dc.citation.endPage | S172 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.66(Suppl. 1) : S169-S172, 2004 | - |
dc.date.modified | 2017-05-04 | - |
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