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CTX-M형 extended-spectrum β-lactamase 생성 Escherichia coli의 확산 및 CTX-M-12의 출현

Other Titles
 Dissemination of CTX-M Type Extended-Spectrum -Lactamases and Emergence of CTX-M-12 in Escherichia coli 
Authors
 오지은  ;  홍종식  ;  배일권  ;  송은향  ;  정석훈  ;  이경원  ;  용동은  ;  이종욱  ;  이위교  ;  강정옥  ;  안지영  ;  홍성근  ;  신종희  ;  어영  ;  박연준  ;  김의종  ;  곽효선  ;  우건조 
Citation
 Korean Journal of Laboratory Medicine (대한진단검사의학회지), Vol.25(4) : 252-258, 2005 
Journal Title
 Korean Journal of Laboratory Medicine (대한진단검사의학회지) 
ISSN
 1598-6535 
Issue Date
2005
Abstract
Background :Clinical isolates of Escherichia coli were evaluated to determine the prevalence and genotypes of Ambler class A extended-spectrum -lactamases (ESBLs Method :Clinical isolates of E. coli were collected from 12 hospitals from February through July, 2004. Antimicrobial susceptibility was tested by disk diffusion and agar dilution methods, and ESBLproduction was determined by double-disk synergy test. TEM, SHV, CTX-M, PER-1, VEB, IBC, GES, and TLA type ESBL genes were detected by PCR amplifications, and the PCR products were subjected to direct sequencing. Result :The double-disk synergy test was positive in 90.9% (149 in 164) of the ceftazidime- or cefotaxime-resistant E. coli isolates. The most prevalent types of Ambler class A ESBLs in E. coli isolates were CTX-M-15 (n=53). CTX-M-14 (n=24), CTX-M-3 (n=9), CTX-M-9 (n=3), CTX-M-12 (n=3), SHV-2a (n=1), SHV-12 (n=5) and TEM-52 (n=3) were also found. CTX-M-12 ESBL had never been reported before in Korea. Conclusion :CTX-M type ESBL-producing E. coli isolates are spreading and CTX-M-12 is emerging in Korea.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151453
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