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Optimal end-tidal sevoflurane concentration for the removal of the laryngeal mask airway in anesthetized adults

Authors
 Yon Hee Shim  ;  Cheung Soo Shin  ;  Chul Ho Chang  ;  Yang-Sik Shin 
Citation
 ANESTHESIA AND ANALGESIA, Vol.101(4) : 1034-1037, 2005 
Journal Title
ANESTHESIA AND ANALGESIA
ISSN
 0003-2999 
Issue Date
2005
MeSH
Adult ; Anesthetics, Inhalation/pharmacokinetics* ; Dose-Response Relationship, Drug ; Humans ; Laryngeal Masks* ; Methyl Ethers/pharmacokinetics* ; Methyl Ethers/pharmacology ; Middle Aged ; Pulmonary Alveoli/metabolism* ; Sevoflurane
Keywords
16192515
Abstract
Sevoflurane provides smooth and rapid emergence from anesthesia and can be used when the removal of a laryngeal mask airway (LMA) is required in anesthetized patients. We sought to determine the optimal end-tidal concentrations of sevoflurane required for the removal of LMA in anesthetized adults. We studied 35 adults, aged 22–64 years old with an ASA physical status I or II, who were undergoing perineal surgery. General anesthesia was induced with thiopental, and the LMA was then inserted. Anesthesia was maintained with sevoflurane, oxygen, and air. After the surgery, the target concentration was maintained for at least 10 min, and then the LMA was removed. Each target concentration at the time of removal was predetermined by the Dixon up-down method (with 0.1% as a step size) starting at 1.7% end-tidal concentra-tion of sevoflurane. The LMA removal was considered successful when there was no coughing, clenching of teeth, or gross purposeful movements during or within 1 min after removal and also if there was no breath holding, laryngospasm, or desaturation after removal. The end-tidal concentration of sevoflurane to achieve successful LMA removal in 50% of adults was 0.99% ± 0.09% (mean ± sd) and in 95% of adults was 1.18% (95% confidence limits, 1.07%–1.79%). In conclusion, we have determined that LMA removal in 50% and 95% of anesthetized adults can be safely accomplished without coughing, moving, or any other airway complications at 0.99% and 1.18% end-tidal concentrations of sevoflurane.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000539-200510000-00019&LSLINK=80&D=ovft
DOI
10.1213/01.ane.0000166977.17442.63
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yang Sik(신양식)
Shin, Cheung Soo(신증수) ORCID logo https://orcid.org/0000-0001-7829-8458
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Chang, Chul Ho(장철호) ORCID logo https://orcid.org/0000-0001-5647-8298
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151442
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