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Treatment Strategy of Multiple Hemangioblastomas

 Eui Hyun Kim  ;  Yong Sook Park  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Yong Gou Park 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.38(3) : 184-189, 2005 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
Multiple hemangioblastomas ; Posterior cranial fossa ; Surgical resection ; Radiosurgery
Multiple hemangioblastomas ; Posterior cranial fossa ; Surgical resection ; Radiosurgery
Objective:Hemangioblastomas are highly vascular and benign neoplasm of the central nervous system(CNS). They can often be found as multiple lesions, as is commonly observed in von Hippel-Lindau(VHL) disease. The aim of this study is to determine the proper management for multiple hemangioblastomas.

Methods:Since 1990, 78cases of hemangioblastoma have been encountered. Among these, 9cases were multiple hemangioblastomas that were treated with surgical resection with or without radiosurgery. The medical, radiological, surgical and histological records were reviewed retrospectively and analyzed statistically.

Results:Nine patients presented with multiple hemangioblastomas and were diagnosed as VHL disease. The mean follow-up duration was 75.7months (6.6~159.2months) after the first surgical treatment. Three patients were treated with surgical resection alone and six patients were treated by both surgical resection and radiosurgery. Twenty-one surgical procedures (13 surgical resections and 8 radiosurgery) were performed. One patient required ventriculoperitoneal shunt and a posterior fossa decompressive craniectomy because of post-radiation brain swelling. Another patient refused additional treatment for the newly developed lesions after the successful treatment of initial lesions. The other patient who presented with numerous lesions in the whole brain and spine underwent cranio-spinal irradiation. Remaining patients showed good results.

Conclusion:The surgical outcomes for the patients with a single lesion of the CNS hemangioblastoma are favorable. However, the treatment of multiple hemangioblastoma is more difficult, and should be treated by surgical resection and radiosurgery with careful consideration.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Park, Yong Sook(박용숙)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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