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만성 폐쇄성 폐질환 환자에서 Tiotropium 1일 1회, 1회 18㎍ 요법과 Ipratropium 1일 4회, 1회 40㎍ 요법의 치료효과 및 안전성 비교
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성규 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김형중 | - |
dc.contributor.author | 안철민 | - |
dc.date.accessioned | 2017-10-26T06:45:26Z | - |
dc.date.available | 2017-10-26T06:45:26Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151257 | - |
dc.description.abstract | Background : This study compared the bronchodilator efficacy and safety of tiotropium inhalation capsules (18㎍once daily) with a ipratropium metered dose inhaler (2 puffs of 20㎍ q.i.d.) in patients with chronic obstructive pulmonary disease (COPD). Method : After the initial screening assessment and a two-week run-in period, patients received either tiotropium 18㎍once daily or ipratropium 40㎍four times daily over a period of 4 weeks in a double blind, double dummy, parallel group study. The outcome measures were the lung function, the daily records of the peak expiratory flow rate (PEFR), the patients´ questionnaire, and the use of concomitant salbutamol. The forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC) were measured 5 minutes before inhalation, and 0.5, 1, 2 and 3 hours after inhaling the study drug on days 0, 14 and 28. Result : In 16 centers, 134 patients with a mean (SD) age of 66 (7) years and a predicted FEV1 of 42 (12)% were analyzed. The trough FEV1 response was significantly higher in the tiotropium group than in the ipratropium group after a four-week treatment period. The weekly mean morning PEFR of the tiotropium group was consistently higher than that of the ipratropium group during the 4-week treatment period with differences ranging from 12.52 to 13.88l/min, which were statistically significant. Tiotropium was well tolerated by the COPD patients during the 4-week treatment period and had a similar safety profile to ipratropium. Conclusion : This study shows that tiotropium administrated once daily has a superior bronchodilator effect with a similar safety profile in treating COPD patients compared with ipratropium, inhaled four times daily. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Tiotropium | - |
dc.subject.MESH | Ipratropium | - |
dc.subject.MESH | COPD | - |
dc.subject.MESH | Efficacy | - |
dc.subject.MESH | Safety | - |
dc.title | 만성 폐쇄성 폐질환 환자에서 Tiotropium 1일 1회, 1회 18㎍ 요법과 Ipratropium 1일 4회, 1회 40㎍ 요법의 치료효과 및 안전성 비교 | - |
dc.title.alternative | A Comparison of Tiotropium 18㎍, Once Daily and Ipratropium 40㎍, 4 Times Daily in a Double-Blind, Double-Dummy, Efficacy and Safety Study in Adults with Chronic Obstructive Pulmonary Disease | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 김승준 | - |
dc.contributor.googleauthor | 김명숙 | - |
dc.contributor.googleauthor | 이상학 | - |
dc.contributor.googleauthor | 김영균 | - |
dc.contributor.googleauthor | 문화식 | - |
dc.contributor.googleauthor | 박성학 | - |
dc.contributor.googleauthor | 이상엽 | - |
dc.contributor.googleauthor | 인광호 | - |
dc.contributor.googleauthor | 이창률 | - |
dc.contributor.googleauthor | 김영삼 | - |
dc.contributor.googleauthor | 김형중 | - |
dc.contributor.googleauthor | 안철민 | - |
dc.contributor.googleauthor | 김성규 | - |
dc.contributor.googleauthor | 김경록 | - |
dc.contributor.googleauthor | 차승익 | - |
dc.contributor.googleauthor | 정태훈 | - |
dc.contributor.googleauthor | 김미옥 | - |
dc.contributor.googleauthor | 박성수 | - |
dc.contributor.googleauthor | 최천웅 | - |
dc.contributor.googleauthor | 유지홍 | - |
dc.contributor.googleauthor | 강홍모 | - |
dc.contributor.googleauthor | 고원중 | - |
dc.contributor.googleauthor | 함형석 | - |
dc.contributor.googleauthor | 강은혜 | - |
dc.contributor.googleauthor | 권오정 | - |
dc.contributor.googleauthor | 이양덕 | - |
dc.contributor.googleauthor | 이흥범 | - |
dc.contributor.googleauthor | 이용철 | - |
dc.contributor.googleauthor | 이양근 | - |
dc.contributor.googleauthor | 신원혁 | - |
dc.contributor.googleauthor | 권성연 | - |
dc.contributor.googleauthor | 김우진 | - |
dc.contributor.googleauthor | 이철규 | - |
dc.contributor.googleauthor | 김영환 | - |
dc.contributor.googleauthor | 심영수 | - |
dc.contributor.googleauthor | 한성구 | - |
dc.contributor.googleauthor | 박혜경 | - |
dc.contributor.googleauthor | 김윤성 | - |
dc.contributor.googleauthor | 이민기 | - |
dc.contributor.googleauthor | 박순규 | - |
dc.contributor.googleauthor | 김미혜 | - |
dc.contributor.googleauthor | 리원연 | - |
dc.contributor.googleauthor | 용석중 | - |
dc.contributor.googleauthor | 신계철 | - |
dc.contributor.googleauthor | 최병휘 | - |
dc.contributor.googleauthor | 오연목 | - |
dc.contributor.googleauthor | 임채만 | - |
dc.contributor.googleauthor | 이상도 | - |
dc.contributor.googleauthor | 김우성 | - |
dc.contributor.googleauthor | 김동순 | - |
dc.contributor.googleauthor | 정성수 | - |
dc.contributor.googleauthor | 김주옥 | - |
dc.contributor.googleauthor | 고영춘 | - |
dc.contributor.googleauthor | 김영철 | - |
dc.contributor.googleauthor | 유남수 | - |
dc.identifier.doi | OAK-2005-05468 | - |
dc.contributor.localId | A00564 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01158 | - |
dc.contributor.localId | A02269 | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.relation.journalsince | 2004~ | - |
dc.relation.journalbefore | ~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) | - |
dc.subject.keyword | Tiotropium | - |
dc.subject.keyword | Ipratropium | - |
dc.subject.keyword | COPD | - |
dc.subject.keyword | Efficacy | - |
dc.subject.keyword | Safety | - |
dc.contributor.alternativeName | Kim, Sung Kyu | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Ahn, Chul Min | - |
dc.contributor.affiliatedAuthor | 김성규 | - |
dc.citation.volume | 58 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 498 | - |
dc.citation.endPage | 506 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.58(5) : 498-506, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43978 | - |
dc.type.rims | ART | - |
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