Cited 16 times in
Silica Induces Human Cyclooxygenase-2 Gene Expression Through the NF-kB Signaling Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2017-10-26T06:44:31Z | - |
dc.date.available | 2017-10-26T06:44:31Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0731-8898 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151238 | - |
dc.description.abstract | Silica is a causative factor of acute cell injury in pulmonary fibrosis. Inducible cyclooxygenase-2 (COX-2) was suggested to play a role in the process of inflammation and fibrosis. We report that silica induces COX-2 expression in WI-38 fibroblasts. Further analysis showed that silica activated the transcription of COX-2 gene primarily via a nuclear factor (NF)-kB binding site in the promoter. NF-kB-inducing kinase (NIK) and TGF-k activated kinase 1 (TAK1), the upstream signaling molecules of NF-kB, are involved in the silica-mediated COX-2 expression. The Electrophoretic Mobility Shift Assay (EMSA) showed that silica induced the direct binding of NF-kB on the putative binding site in COX-2 promoter. These results suggest that silica activates the human COX-2 gene transcription through the induction of NF-kB activity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Begell House | - |
dc.relation.isPartOf | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Binding Sites/drug effects | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Induction | - |
dc.subject.MESH | Fibroblasts/drug effects* | - |
dc.subject.MESH | Fibroblasts/enzymology | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MAP Kinase Kinase Kinases/metabolism | - |
dc.subject.MESH | Membrane Proteins | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases/genetics* | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases/metabolism | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Silicon Dioxide/toxicity* | - |
dc.title | Silica Induces Human Cyclooxygenase-2 Gene Expression Through the NF-kB Signaling Pathway | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jung-Kyoung Choi | - |
dc.contributor.googleauthor | Seok-Geun Lee | - |
dc.contributor.googleauthor | Joo Yong Lee | - |
dc.contributor.googleauthor | Hae-Yun Nam | - |
dc.contributor.googleauthor | Woon-kyu Lee | - |
dc.contributor.googleauthor | Kweon-Haeng Lee | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Young Lim | - |
dc.identifier.doi | 10.1615/JEnvPathToxOncol.v24.i3.30 | - |
dc.contributor.localId | A01158 | - |
dc.relation.journalcode | J01400 | - |
dc.identifier.eissn | 2162-6537 | - |
dc.identifier.pmid | 16050801 | - |
dc.identifier.url | http://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,3514f0af2eca0266,7c0ceb553e486760.html | - |
dc.subject.keyword | 16050801 | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | 김형중 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 174 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, Vol.24(3) : 163-174, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43960 | - |
dc.type.rims | ART | - |
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