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Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats

DC FieldValueLanguage
dc.contributor.author김기준-
dc.contributor.author김기준-
dc.date.accessioned2017-10-26T06:44:02Z-
dc.date.available2017-10-26T06:44:02Z-
dc.date.issued2005-
dc.identifier.issn0165-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151227-
dc.description.abstractRegulators of G protein signaling (RGS) proteins are GTPase-activating proteins which act as modulators of G-protein-coupled receptors. RGS9 has two alternative splicing variants. RGS9-1 is expressed in the retina. RGS9-2 is expressed in the brain, especially abundant in the striatum. It is believed to be an essential regulatory component of dopamine and opioid signaling. In this study, we compared the expression of RGS9 proteins in the nervous system of different age groups of rats employing immunocytochemistry. In both 3-week- and 1-year-old rats, RGS9 is expressed abundantly in caudate–putamen, nucleus accumbens, and olfactory tubercle. It is also expressed abundantly in the ventral horn of the spinal cord and the dorsal root ganglion (DRG) cells. Quantitative analysis showed that the intensities of RGS9 expression in 1-year-old rats are higher than those in the 3-week-old rats in caudate–putamen, nucleus accumbens, olfactory tubercle, periaqueductal gray, and gray matter of the spinal cord. In contrast, in thalamic nuclei and locus coeruleus, the intensities of RGS9 immunostaining in 3-week-old rats are higher than in 1-year-old rats. In DRG cells, there is no significant difference between the two age groups. These data suggest that RGS9 is differentially expressed with age. Such differential expression may play an important role in neuronal differentiation and development as well as in neuronal function, such as dopamine and opioid signaling.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Publishers-
dc.relation.isPartOfBrain Research. Developmental Brain Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAfferent Pathways/growth & development*-
dc.subject.MESHAfferent Pathways/metabolism-
dc.subject.MESHAge Factors-
dc.subject.MESHAging/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHBrain/growth & development-
dc.subject.MESHBrain/metabolism-
dc.subject.MESHGanglia, Spinal/growth & development-
dc.subject.MESHGanglia, Spinal/metabolism-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHNervous System/growth & development*-
dc.subject.MESHNervous System/metabolism-
dc.subject.MESHNeurons, Afferent/metabolism-
dc.subject.MESHNociceptors/physiology*-
dc.subject.MESHPain/metabolism*-
dc.subject.MESHPain/physiopathology-
dc.subject.MESHRGS Proteins/metabolism*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSpinal Cord/growth & development-
dc.subject.MESHSpinal Cord/metabolism-
dc.subject.MESHSynaptic Transmission/physiology-
dc.subject.MESHUp-Regulation/physiology-
dc.titleDifferential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorKi Jun Kim-
dc.contributor.googleauthorKumi Moriyama-
dc.contributor.googleauthorKyung Ream Han-
dc.contributor.googleauthorManohar Sharma-
dc.contributor.googleauthorXiaokang Han-
dc.contributor.googleauthorGuo-xi Xie-
dc.contributor.googleauthorPamela Pierce Palmer-
dc.identifier.doi10.1016/j.devbrainres.2005.08.003-
dc.contributor.localIdA00340-
dc.contributor.localIdA00340-
dc.relation.journalcodeJ00395-
dc.relation.journalsince1988~2005-
dc.identifier.pmid16153714-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0165380605002336-
dc.subject.keywordStriatum-
dc.subject.keywordGTPase-activating protein-
dc.subject.keywordDopamine-
dc.subject.keywordOpioid-
dc.subject.keywordAging-
dc.subject.keywordDevelopment-
dc.subject.keywordRGS (regulator of G protein signaling)-
dc.contributor.alternativeNameKim, Ki Jun-
dc.contributor.alternativeNameKim, Ki Jun-
dc.contributor.affiliatedAuthor김기준-
dc.citation.volume160-
dc.citation.number1-
dc.citation.startPage28-
dc.citation.endPage29-
dc.identifier.bibliographicCitationBrain Research. Developmental Brain Research, Vol.160(1) : 28-29, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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