Cited 58 times in
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.date.accessioned | 2017-10-26T06:40:43Z | - |
dc.date.available | 2017-10-26T06:40:43Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151160 | - |
dc.description.abstract | PURPOSE: Caspase-14 is unique among caspase family proteases in that its proteolytic processing has been principally associated with epithelial cell differentiation rather than apoptosis or inflammation. We investigated caspase-14 expression in several types of human epithelial malignancy by immunohistochemistry, correlating results with stage, histologic grade, and patient survival. EXPERIMENTAL DESIGN: Tumor-associated alterations in caspase-14 expression were observed for cervical, ovarian, breast, gastric, and colon cancers. RESULTS: In cervical (n = 445), ovarian (n = 91), and colon (n = 106) specimens, expression of caspase-14 was significantly reduced in cancers compared with normal epithelium. Decreases in caspase-14 immunopositivity correlated with the histologic progression of cervical cancer (P < 0.0001, ANOVA). In localized gastric cancers, caspase-14 immunostaining was significantly lower in poorly differentiated tumors compared with well-differentiated tumors (P = 0.02, Pearson's chi(2) analysis). Lower caspase-14 expression was associated with advanced clinical stage in ovarian cancer (P = 0.04, ANOVA) and with shorter overall survival among ovarian cancer patients with serous tumors (n = 62) in both univariate (P = 0.005) and multivariate (P = 0.03) analysis. Lower caspase-14 expression correlated with shorter overall survival among patients with T(3)N(0)M(0) stage gastric cancers (n = 94; P = 0.006, log-rank test). In contrast to cervical, ovarian, and colon cancers, caspase-14 expression was increased in ductal carcinoma in situ and invasive cancers compared with normal mammary epithelium (P = 0.001, t test). CONCLUSIONS: The findings reveal tumor-specific alterations in caspase-14 expression and suggest that differences in its expression may define subsets of epithelial cancers with distinct clinical behaviors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Association for Cancer Research | - |
dc.relation.isPartOf | CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Maryla Krajewska | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.contributor.googleauthor | Susan Kennedy | - |
dc.contributor.googleauthor | Michael J. Duffy | - |
dc.contributor.googleauthor | Yick F. Wong | - |
dc.contributor.googleauthor | David Marr | - |
dc.contributor.googleauthor | Jowita Mikolajczyk | - |
dc.contributor.googleauthor | Ahmed Shabaik | - |
dc.contributor.googleauthor | Ivo Meinhold-Heerlein | - |
dc.contributor.googleauthor | Xianshu Huang | - |
dc.contributor.googleauthor | Steven Banares | - |
dc.contributor.googleauthor | Hirad Hedayat | - |
dc.contributor.googleauthor | John C. Reed | - |
dc.contributor.googleauthor | Stan Krajewski | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-04-2527 | - |
dc.contributor.localId | A01183 | - |
dc.relation.journalcode | J00564 | - |
dc.identifier.pmid | 10.1158/1078-0432.CCR-04-2527 | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.citation.volume | 11 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5462 | - |
dc.citation.endPage | 5471 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, Vol.11(15) : 5462-5471, 2005 | - |
dc.date.modified | 2017-05-04 | - |
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