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제2형 당뇨병 환자에서 아디포넥틴 유전자의 다형성과 경동맥 내중막두께

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김경래-
dc.contributor.author김소헌-
dc.contributor.author박세은-
dc.contributor.author박소영-
dc.contributor.author안철우-
dc.contributor.author이현주-
dc.contributor.author이현철-
dc.contributor.author임승길-
dc.contributor.author차봉수-
dc.contributor.author한승진-
dc.contributor.author허규연-
dc.date.accessioned2017-10-26T06:39:49Z-
dc.date.available2017-10-26T06:39:49Z-
dc.date.issued2005-
dc.identifier.issn2093-596X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151149-
dc.description.abstractBackground: The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients. Methods: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined. Results: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013) Conclusions: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Endocrine Society-
dc.relation.isPartOfEndocrinology and Metabolism (대한내분비학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin-
dc.subject.MESHACDC-
dc.subject.MESHSNP-
dc.subject.MESHIMT (Intima-Media thickness)-
dc.subject.MESHType 2 diabetes-
dc.title제2형 당뇨병 환자에서 아디포넥틴 유전자의 다형성과 경동맥 내중막두께-
dc.title.alternativeAdiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor강은석-
dc.contributor.googleauthor박소영-
dc.contributor.googleauthor김소헌-
dc.contributor.googleauthor이현주-
dc.contributor.googleauthor허규연-
dc.contributor.googleauthor한승진-
dc.contributor.googleauthor박세은-
dc.contributor.googleauthor김형진-
dc.contributor.googleauthor안철우-
dc.contributor.googleauthor차봉수-
dc.contributor.googleauthor임승길-
dc.contributor.googleauthor김경래-
dc.contributor.googleauthor이현철-
dc.identifier.doi10.3803/jkes.2005.20.1.29-
dc.contributor.localIdA00068-
dc.contributor.localIdA00294-
dc.contributor.localIdA00624-
dc.contributor.localIdA01521-
dc.contributor.localIdA01527-
dc.contributor.localIdA02270-
dc.contributor.localIdA03297-
dc.contributor.localIdA03301-
dc.contributor.localIdA03375-
dc.contributor.localIdA03996-
dc.contributor.localIdA04302-
dc.contributor.localIdA04343-
dc.relation.journalcodeJ00773-
dc.identifier.eissn2093-5978-
dc.relation.journalsince2011~-
dc.identifier.pmid10.3803/jkes.2005.20.1.29-
dc.relation.journalbefore~2010 Journal of Korea Society of Endocrinology (대한내분비학회지)-
dc.subject.keywordAdiponectin-
dc.subject.keywordACDC-
dc.subject.keywordSNP-
dc.subject.keywordIMT (Intima-Media thickness)-
dc.subject.keywordType 2 diabetes-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameKim, So Hun-
dc.contributor.alternativeNamePark, Se Eun-
dc.contributor.alternativeNamePark, So Young-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Joo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHan, Seung Jin-
dc.contributor.alternativeNameHur, Kyu Yeon-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPage29-
dc.citation.endPage39-
dc.identifier.bibliographicCitationEndocrinology and Metabolism (대한내분비학회지), Vol.20(1) : 29-39, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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