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제2형 당뇨병 환자에서 아디포넥틴 유전자의 다형성과 경동맥 내중막두께
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 김소헌 | - |
dc.contributor.author | 박세은 | - |
dc.contributor.author | 박소영 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현주 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 한승진 | - |
dc.contributor.author | 허규연 | - |
dc.date.accessioned | 2017-10-26T06:39:49Z | - |
dc.date.available | 2017-10-26T06:39:49Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151149 | - |
dc.description.abstract | Background: The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients. Methods: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined. Results: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013) Conclusions: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism (대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin | - |
dc.subject.MESH | ACDC | - |
dc.subject.MESH | SNP | - |
dc.subject.MESH | IMT (Intima-Media thickness) | - |
dc.subject.MESH | Type 2 diabetes | - |
dc.title | 제2형 당뇨병 환자에서 아디포넥틴 유전자의 다형성과 경동맥 내중막두께 | - |
dc.title.alternative | Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 강은석 | - |
dc.contributor.googleauthor | 박소영 | - |
dc.contributor.googleauthor | 김소헌 | - |
dc.contributor.googleauthor | 이현주 | - |
dc.contributor.googleauthor | 허규연 | - |
dc.contributor.googleauthor | 한승진 | - |
dc.contributor.googleauthor | 박세은 | - |
dc.contributor.googleauthor | 김형진 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.identifier.doi | 10.3803/jkes.2005.20.1.29 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A00624 | - |
dc.contributor.localId | A01521 | - |
dc.contributor.localId | A01527 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03297 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04302 | - |
dc.contributor.localId | A04343 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.eissn | 2093-5978 | - |
dc.relation.journalsince | 2011~ | - |
dc.identifier.pmid | 10.3803/jkes.2005.20.1.29 | - |
dc.relation.journalbefore | ~2010 Journal of Korea Society of Endocrinology (대한내분비학회지) | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | ACDC | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | IMT (Intima-Media thickness) | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Kim, So Hun | - |
dc.contributor.alternativeName | Park, Se Eun | - |
dc.contributor.alternativeName | Park, So Young | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Joo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Han, Seung Jin | - |
dc.contributor.alternativeName | Hur, Kyu Yeon | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism (대한내분비학회지), Vol.20(1) : 29-39, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43486 | - |
dc.type.rims | ART | - |
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