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제2형 당뇨병 환자에서 아디포넥틴 유전자의 다형성과 경동맥 내중막두께

Other Titles
 Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes 
 강은석  ;  박소영  ;  김소헌  ;  이현주  ;  허규연  ;  한승진  ;  박세은  ;  김형진  ;  안철우  ;  차봉수  ;  임승길  ;  김경래  ;  이현철 
 Endocrinology and Metabolism (대한내분비학회지), Vol.20(1) : 29-39, 2005 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
Issue Date
Adiponectin ; ACDC ; SNP ; IMT (Intima-Media thickness) ; Type 2 diabetes
Adiponectin ; ACDC ; SNP ; IMT (Intima-Media thickness) ; Type 2 diabetes
Background: The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients.

Methods: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined.

Results: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013)

Conclusions: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Kim, So Hun(김소헌)
Park, Se Eun(박세은)
Park, So Young(박소영)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Joo(이현주)
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Seung Jin(한승진)
Hur, Kyu Yeon(허규연)
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