Cited 66 times in
Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors
DC Field | Value | Language |
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dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2017-10-26T06:39:15Z | - |
dc.date.available | 2017-10-26T06:39:15Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1096-6080 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151138 | - |
dc.description.abstract | Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and food contaminants with known or suspected carcinogenic properties. In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPARα) and delta (PPARβ/δ) in cell culture systems. Luciferase reporter systems were employed and several PAHs were evaluated for their ability to activate EGR-1 and PPARs. Some PAHs enhanced EGR-1 expression and activated PPARα and PPARβ. Among them, benz(a)anthracene was found to act as a relatively potent activator of PPARα and PPARβ/δ, and to significantly enhance EGR-1 transcription. These in vitro assays were confirmed by Western blot analysis, using cell lysates of tissue samples from mouse trapped at a highly contaminated Superfund site in the Chattanooga Creek floodplain in Chattanooga, Tennessee. We have found that a PPAR target gene, glycogen synthase kinase-3β (GSK-3β), was down-regulated and EGR-1 was up-regulated in the mouse samples of Chattanooga Creek. In addition, select PAHs repressed GSK-3β and induced CYP4A in FaO rat hepatoma cells. In conclusion, PAHs activate PPARα and PPARβ/δ, and up-regulate EGR-1 expression in vitro as well as in vivo. These data may provide a diversity of PAH activity in several biological pathways. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | TOXICOLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | PAHs | - |
dc.subject.MESH | PPARa | - |
dc.subject.MESH | PPARd | - |
dc.subject.MESH | EGR-1 | - |
dc.subject.MESH | GSK-3b | - |
dc.title | Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.contributor.googleauthor | Kiyoshi Yamaguchi | - |
dc.contributor.googleauthor | Seong-Ho Lee | - |
dc.contributor.googleauthor | Patricia K. Tithof | - |
dc.contributor.googleauthor | Gary S. Sayler | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Seung Joon Baek | - |
dc.identifier.doi | 10.1093/toxsci/kfi118 | - |
dc.contributor.localId | A02604 | - |
dc.relation.journalcode | J02740 | - |
dc.identifier.eissn | 1096-0929 | - |
dc.identifier.pmid | 10.1093/toxsci/kfi118 | - |
dc.subject.keyword | PAHs | - |
dc.subject.keyword | PPARa | - |
dc.subject.keyword | PPARd | - |
dc.subject.keyword | EGR-1 | - |
dc.subject.keyword | GSK-3b | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.citation.volume | 85 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 585 | - |
dc.citation.endPage | 593 | - |
dc.identifier.bibliographicCitation | TOXICOLOGICAL SCIENCES, Vol.85(1) : 585-593, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43477 | - |
dc.type.rims | ART | - |
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