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한국인 제2형 당뇨병환자에서 homeostasis model assessment 법을 이용한 인슐린저항성 및 인슐린 분비장애의 상대적 중요성에 대한 평가

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김경래-
dc.contributor.author문재훈-
dc.contributor.author심완섭-
dc.contributor.author안철우-
dc.contributor.author이유미-
dc.contributor.author이현철-
dc.contributor.author임승길-
dc.contributor.author차봉수-
dc.date.accessioned2017-10-26T06:37:33Z-
dc.date.available2017-10-26T06:37:33Z-
dc.date.issued2005-
dc.identifier.issn1015-6461-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151095-
dc.description.abstractBACKGROUND: Type 2 diabetes is characterized by defects in both insulin secretion and insulin sensitivity. However, the relative importance of insulin secretion and insulin resistance in Korean type 2 diabetic patients has not been well characterized in any study that has included a large number of subjects. Therefore, this study aimed to evaluate the relative importance of insulin sensitivity and the function of the beta cell in Korean type 2 diabetic patients. METHODS: We applied the HOMA model to 1,162 type 2 diabetic patients (654 males and, 508 females) who did not use insulin and we assessed HOMAIR and HOMAbetacell & its relation to the other parameters. RESULTS: The HOMAIR of Korean type 2 diabetic patients was 2.29(range: 0.31~37.17) and the HOMAbetacell of Korean type 2 diabetic patients was 32.17(range: 1.04~1310.79). The HOMAIR of Korean type 2 diabetic male patients was 2.15(range: 0.31~16.6) and that of Korean type 2 diabetic female patients was 2.47(range: 0.36~37.17). The HOMAbetacell of Korean type 2 diabetic male patients was 30.1(range: 1.04~462.34) and that of Korean type 2 diabetic female patients was 35.42(range: 2.60~1310.79). The HOMAIR and HOMAbetacell were significantly higher in females than males. There was no significant correlation between HOMAIR and age, and the duration of diabetes, but there was significant correlation between HOMAIR and BMI, fasting glucose, HbA1c and the fasting insulin. There was no significant correlation between age and HOMAbetacell. However, there was significant correlation between HOMAbetacell and BMI, the duration of diabetes, the fasting glucose, HbA1c and the fasting insulin. The longer the duration of diabetes, the more the HOMAbetacell was decreased but there was no change of HOMAIR with respect to the duration of diabetes. As expected, the subjects with a lower HOMAIR and a higher HOMAbetacell had the best glycemic control. Those with a higher HOMAIR and lower HOMAbetacell had the worst glycemic control although they had taken larger amount of oral hypoglycemic agents. Interestingly, the patients with a lower HOMAIR and higher HOMAbetacell had better glycemic control than those patients with a higher HOMAIR and lower HOMAbetacell. CONCLUSION: Both insulin secretion and insulin resistance are important in glycemic control but it seems that insulin secretion is a more important factor in glycemic control than insulin resistance in the Korean type 2 diabetic patients.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한당뇨병학회-
dc.relation.isPartOfJournal of Korean Diabetes Association (당뇨병)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHType 2 diabetes mellitus-
dc.subject.MESHHomeostasis model assessment-
dc.subject.MESHInsulin secretion-
dc.subject.MESHInsulin resistance-
dc.title한국인 제2형 당뇨병환자에서 homeostasis model assessment 법을 이용한 인슐린저항성 및 인슐린 분비장애의 상대적 중요성에 대한 평가-
dc.title.alternativeAnalysis of the Relative Importance of Insulin Resistance and Insulin Secretion Defect by Homeostasis Model Assessment in Korean Type 2 Diabetic Patients-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor심완섭-
dc.contributor.googleauthor김수경-
dc.contributor.googleauthor김혜진-
dc.contributor.googleauthor문재훈-
dc.contributor.googleauthor강은석-
dc.contributor.googleauthor이유미-
dc.contributor.googleauthor안철우-
dc.contributor.googleauthor임승길-
dc.contributor.googleauthor김경래-
dc.contributor.googleauthor이현철-
dc.contributor.googleauthor차봉수-
dc.identifier.doiOAK-2005-04839-
dc.contributor.localIdA00068-
dc.contributor.localIdA00294-
dc.contributor.localIdA01378-
dc.contributor.localIdA02199-
dc.contributor.localIdA02270-
dc.contributor.localIdA03012-
dc.contributor.localIdA03301-
dc.contributor.localIdA03375-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ01508-
dc.relation.journalsince1977~2007-
dc.relation.journalafter~2008 Korean Diabetes Journal-
dc.subject.keywordType 2 diabetes mellitus-
dc.subject.keywordHomeostasis model assessment-
dc.subject.keywordInsulin secretion-
dc.subject.keywordInsulin resistance-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameMoon, Jae Hoon-
dc.contributor.alternativeNameShim, Wan Sub-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCha, Bong Soo-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage206-
dc.citation.endPage214-
dc.identifier.bibliographicCitationJournal of Korean Diabetes Association (당뇨병), Vol.29(3) : 206-214, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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