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Intracellular translocation of superparamagnetic iron oxide nanoparticles encapsulated with peptide-conjugated poly(D,L lactide-co-glycolide)

Authors
 Lee, Seung-Jun  ;  Jong-Ryul Jeong  ;  Shin, Sung-Chul  ;  Yong-Min Huh  ;  Song, Ho-Taek  ;  Jin-Suck Suh  ;  Chang, Young-Hwan  ;  Jeon, Bong-Sik  ;  Kim, Jong-Duk 
Citation
 Journal of Applied Physics, Vol.97(10) : 1-3, 2005 
Journal Title
 Journal of Applied Physics 
ISSN
 0021-8979 
Issue Date
2005
Abstract
In this study, we propose the use of iron oxide nanoparticle encapsulated with peptide-conjugated poly(D,L lactide-co-glycolide) (PLGA) as a potent intracellular carrier for diagnosis agent. The iron oxide (γ-Fe2O3) nanoparticles were prepared by a chemical coprecipitation method of ferric and ferrous ions in an alkali solution. Arg peptide (RRRRRRRRCK-FITC) were conjugated to the PLGA via a simple coupling reaction between maleimide-derivatized PLGA and thiol-terminated Arg peptide. The γ-Fe2O3-PLGA-Arg-FITC nanoparticle was then prepared by an emulsification-diffusion technique. A confocal laser scanning microscopy revealed that the γ-Fe2O3-PLGA-Arg-FITC nanoparticle was effectively adsorbed onto the membrane of stem cells and delivered into the nuclei without cytotoxicity. Magnetic properties of the γ-Fe2O3-PLGA-Arg-FITC nanoparticle were observed by measuring the zero-field-cooled/field-cooled magnetization and magnetic hysteresis loop using a superconducting quantum interference device magnetometer from 5 K to 300 K.
Full Text
http://scitation.aip.org/content/aip/journal/jap/97/10/10.1063/1.1853933
DOI
10.1063/1.1853933
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151069
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