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In Vivo Antihepatotoxic Effects of Ligularia fischeri var. spiciformis and the Identification of the Active Component, 3,4-Dicaffeoylquinic Acid

Authors
 Jongwon Choi  ;  Jung-Kwan Park  ;  Kyung-Tae Lee  ;  Kwang-Kyun Park  ;  Won-Bae Kim  ;  Jin-Ha Lee  ;  Hyun-Ju Jung  ;  Hee-Juhn Park 
Citation
 JOURNAL OF MEDICINAL FOOD, Vol.8(3) : 348-352, 2005 
Journal Title
 JOURNAL OF MEDICINAL FOOD 
ISSN
 1096-620X 
Issue Date
2005
MeSH
antihepatotoxicity ; cholestasis ; 3,4-dicaffeoylquinic acid ; Ligularia fischeri var. spiciformis
Keywords
antihepatotoxicity ; cholestasis ; 3,4-dicaffeoylquinic acid ; Ligularia fischeri var. spiciformis
Abstract
Pretreatment with a methanolic extract of Ligularia fischeri var. spiciformis (Compositae) herb inhibited hepatotoxicities caused by CCl4, D-galactosamine (GalN), α-naphthylisothiocyanate (ANIT), and DL-ethionine in rats. An ethyl acetate (EtOAc) extract fractionated from the methanolic extract showed a strong inhibitory effect. A major component, 3,4- dicaffeoylquinic acid (DCQA), isolated from the methanolic extract was examined for antihepatotoxicity. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases (alanine and aspartate), sorbitol dehydrogenase, γ-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. DCQA also partially restored bile flow and reduced total bilirubin and cholic acid concentrations in rats with ANIT-induced cholestasis. Treatment with DCQA inhibited the increase in triglyceride, cholesterol, and total lipids in DL-ethionine-induced fatty liver. These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/jmf.2005.8.348
DOI
10.1089/jmf.2005.8.348.
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151006
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