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Treatment of intravenous immunoglobulin-resistant Kawasaki disease with methotrexate
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 안선영 | - |
dc.date.accessioned | 2017-10-26T06:33:57Z | - |
dc.date.available | 2017-10-26T06:33:57Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0300-9742 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151004 | - |
dc.description.abstract | OBJECTIVE: To evaluate the effect of low-dose oral methotrexate (MTX) as treatment for patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). METHODS: The subjects were four patients with KD, aged 8 months to 8 years old, who showed persistent disease after treatment with high-dose IVIG (2 g/kg) and aspirin (100 mg/kg). These patients were re-treated with IVIG and were also treated with IV dexamethasone (0.3 mg/kg). IV dexamethasone induced defervescence in three patients, but fever recurred upon discontinuing the steroid. One patient showed no response to either IVIG or dexamethasone. All patients were subsequently treated weekly with low-dose oral MTX [10 mg/body surface area (BSA)]. RESULTS: MTX treatment resulted in rapid defervescence, improvement in clinical symptoms, and normalization of acute-phase reactants in all patients. There was no progression of coronary artery dilatation and MTX was discontinued with no recurrence of fever. No adverse effects of MTX were observed. CONCLUSION: Low-dose oral MTX is an effective treatment for refractory KD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Dexamethasone/therapeutic use | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Resistance/drug effects* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fever/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulins, Intravenous/therapeutic use* | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methotrexate/therapeutic use* | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/drug therapy* | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/physiopathology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Treatment of intravenous immunoglobulin-resistant Kawasaki disease with methotrexate | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | S-Y Ahn | - |
dc.contributor.googleauthor | DS Kim | - |
dc.identifier.doi | OAK-2005-04337 | - |
dc.contributor.localId | A00405 | - |
dc.contributor.localId | A02228 | - |
dc.relation.journalcode | J02635 | - |
dc.identifier.eissn | 1502-7732 | - |
dc.identifier.pmid | 16095010 | - |
dc.identifier.url | http://web.a.ebscohost.com/ehost/detail?sid=0de1c701-fe95-4b82-9db6-78895fe26a76%40sessionmgr4002&vid=1&hid=4107&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=mnh&AN=16095010 | - |
dc.subject.keyword | 16095010 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Ahn, Sun Young | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 136 | - |
dc.citation.endPage | 139 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.34(2) : 136-139, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43355 | - |
dc.type.rims | ART | - |
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