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한국인 제2형 당뇨병 환자에서 글루카곤 유사 펩타이드-1 수용체 유전자 다형성
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2017-10-26T06:31:52Z | - |
dc.date.available | 2017-10-26T06:31:52Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1015-6461 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150938 | - |
dc.description.abstract | Background: Glucagon-like peptide-1 (GLP-1) is a hormone secreted by intestinal L-cells, which stimulates insulin secretion from cells. The biological action of GLP-1 is mediated by the glucagon-like peptide-1 receptor (GLP-1R), which is 463 amino acids in size, with 7 transmembrane domains. Because GLP-1 plays an important modulatory role in regulating glucose-stimulated insulin, the GLP-1R could be a candidate gene contributing to impaired -cell function and the development of this genetically heterogeneous disorder. Recently, four GLP-1R SNPs were identified in Caucasian diabetic individuals, and for the SNP at the Leu- 260Phe (A/C) position, statistically significant differences were detected in the distribution of genotypes between type 2 diabetic and nondiabetic subjects. We replicated the genetic association between the SNP at the leu260Phe (A/C) position in the GLP-1R gene and Korean type 2 diabetes mellitus. Methods: The Leu260Phe polymorphism in the GLP-1R gene was determined using a PCR- RFLP method (the genotypes were determined according to the results of polymerase chain reaction products after digestion and the digestive enzyme was BbsI) in 419 Korean type 2 diabetic patients and 345 nondiabetic subjects. Results: In contrast to the Caucasian report, there was no significant difference in the frequencies of alleles, and genotypes between Korean type 2 diabetic and nondiabetic subjects. When analyzed according to gender, BMI and age of onset, the genotype distribution of type 2 diabetic subjects was not significantly different from nondiabetic subjects. Conclusion: The Leu260Phe polymorphism in the GLP-1R gene was not associated with type 2 diabetes mellitus, and we were unable to replicate the genetic association between this polymorphism and Korean type 2 diabetes mellitus | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한당뇨병학회 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Type 2 diabetes mellitus | - |
dc.subject.MESH | Glucagon-like peptide 1 receptor | - |
dc.subject.MESH | Single nucleotide polymorphism | - |
dc.title | 한국인 제2형 당뇨병 환자에서 글루카곤 유사 펩타이드-1 수용체 유전자 다형성 | - |
dc.title.alternative | Genetic Polymorphism of Glucagon-Like Peptide 1 Receptor in Korean Type 2 Diabetes Mellitus | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 이경욱 | - |
dc.contributor.googleauthor | 강미화 | - |
dc.contributor.googleauthor | 박선희 | - |
dc.contributor.googleauthor | 김은아 | - |
dc.contributor.googleauthor | 홍성빈 | - |
dc.contributor.googleauthor | 남문석 | - |
dc.contributor.googleauthor | 김용성 | - |
dc.contributor.googleauthor | 박경수 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.identifier.doi | OAK-2005-05198 | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J01508 | - |
dc.relation.journalsince | 1977~2007 | - |
dc.relation.journalafter | ~2008 Korean Diabetes Journal | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.subject.keyword | Glucagon-like peptide 1 receptor | - |
dc.subject.keyword | Single nucleotide polymorphism | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 30 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.29(1) : 30-38, 2005 | - |
dc.date.modified | 2017-05-04 | - |
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