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Tissue Doppier derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy

DC Field Value Language
dc.contributor.author강석민-
dc.contributor.author임세중-
dc.contributor.author정남식-
dc.contributor.author조정래-
dc.contributor.author최의영-
dc.date.accessioned2017-10-26T06:31:47Z-
dc.date.available2017-10-26T06:31:47Z-
dc.date.issued2005-
dc.identifier.issn0012-3692-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150936-
dc.description.abstractBACKGROUND: Although impaired left ventricular (LV) diastolic function is a prominent feature of hypertrophic cardiomyopathy (HCM), diastolic function and its relation to exercise capacity in apical HCM (ApHCM) has not been explored previously. This study was sought to determine the relationship between diastolic mitral annular velocities combined with conventional Doppler indexes and exercise capacity in patients with ApHCM. PATIENTS: Twenty-nine patients with ApHCM (24 men; mean age +/- SD, 57 +/- 10 years) underwent supine bicycle exercise with simultaneous respiratory gas analysis and two-dimensional and Doppler echocardiographic study. RESULTS: The mitral inflow velocities (early filling [E], late filling, and deceleration time) were traced and measured. Early diastolic mitral annular velocity (E') was measured at the septal corner of mitral annulus by Doppler tissue imaging (DTI) from the apical four-chamber view. Pro-brain natriuretic peptide (proBNP) was measured at the time of echocardiography using a quantitative electrochemiluminescence immunoassay. E/E' ratio correlated inversely with maximal oxygen uptake (Vo(2)max) [r = - 0.47, p = 0.0106]. There was a significant positive correlation between E' and Vo(2)max (r = 0.41, p = 0.024). However, no correlation was found between conventional two-dimensional, Doppler indices, and proBNP and Vo(2)max). Of all the echocardiographic and clinical parameters assessed, E/E' ratio had the best correlation with exercise capacity (r - 0.47) and was the strongest independent predictor of Vo(2)max by multivariate analysis (p = 0.0106). CONCLUSIONS: DTI-derived indexes (E', E/E' ratio), an estimate of myocardial relaxation and LV filling pressures, correlate with exercise capacity in patients with ApHCM, suggesting that abnormal diastolic function may be a factor limiting exercise capacity.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican College of Chest Physicians-
dc.relation.isPartOfCHEST-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCardiomyopathy, Hypertrophic/blood-
dc.subject.MESHCardiomyopathy, Hypertrophic/diagnostic imaging*-
dc.subject.MESHCardiomyopathy, Hypertrophic/physiopathology*-
dc.subject.MESHExercise Test-
dc.subject.MESHExercise Tolerance*-
dc.subject.MESHFemale-
dc.subject.MESHFerrous Compounds-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNatriuretic Peptide, Brain/blood-
dc.subject.MESHOxygen Consumption-
dc.subject.MESHPeptide Fragments/blood-
dc.subject.MESHUltrasonography, Doppler*-
dc.subject.MESHVentricular Dysfunction, Left/diagnostic imaging*-
dc.titleTissue Doppier derived indices predict exercise capacity in patients with apical hypertrophic cardiomyopathy-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorJung-Rae Cho-
dc.contributor.googleauthorJin-Mi Kim-
dc.contributor.googleauthorJeong-Ah Ahn-
dc.contributor.googleauthorEui-Young Choi-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSe-Joong Rim-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.1378/chest.128.5.3428-
dc.contributor.localIdA00037-
dc.contributor.localIdA03372-
dc.contributor.localIdA03585-
dc.contributor.localIdA03903-
dc.contributor.localIdA04165-
dc.relation.journalcodeJ00520-
dc.identifier.eissn1931-3543-
dc.identifier.pmid16304295-
dc.identifier.urlhttp://journal.publications.chestnet.org/article.aspx?articleid=1084055-
dc.subject.keywordapical hypertrophic cardiomyopathy-
dc.subject.keywordDoppler tissue imaging-
dc.subject.keywordexercise capacity-
dc.subject.keywordmitral annular velocity-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameRim, Se Joong-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, Jung Rae-
dc.contributor.alternativeNameChoi, Eui Young-
dc.citation.volume128-
dc.citation.number5-
dc.citation.startPage3428-
dc.citation.endPage3433-
dc.identifier.bibliographicCitationCHEST, Vol.128(5) : 3428-3433, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid42807-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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