Cited 29 times in
Clinical, histological, and immunohistochemical features predicting 1p/19q loss of heterozygosity in oligodendroglial tumors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김태승 | - |
dc.contributor.author | 김호근 | - |
dc.date.accessioned | 2017-10-26T06:30:37Z | - |
dc.date.available | 2017-10-26T06:30:37Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0001-6268 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150896 | - |
dc.description.abstract | To identify a better diagnostic criteria for oligodendroglial tumors, we investigated the clinical, histological, and immunohistochemical features that would be able to predict a 1p/19q loss of heterozygosity (LOH) in these tumors. We performed a PCR-based LOH test with the 1p and 19q microsatellite markers by microdissecting tumor in 56 samples (44 oligodendrogliomas and 12 mixed oligoastrocytomas) of paraffin-embedded tissue. Patients with oligodendroglial tumors with 1p/19q LOH had a statistically significant better prognosis for overall survival. Comparative analysis of several features indicated that the 1p/19q LOH tumors were associated with two histological features, “tumor cellularity” and “perinuclear halo,” and low O 6-methylguanine-DNA-methyltransferase (MGMT) expression and high cytoplasmic glutathione S-transferase pi (GST-π) expression. In addition, the incidence of 1p/19q LOH was infrequent in the youngest age category (less than 20 years old) studied. Using the new features, we could predict the 1p/19q status of oligodendroglial tumors with greater than 90% accuracy. Therefore, applying these features in clinical practice, would be helpful in clarifying oligodendroglial tumor diagnosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ACTA NEUROCHIRURGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Brain Neoplasms/diagnosis* | - |
dc.subject.MESH | Brain Neoplasms/genetics* | - |
dc.subject.MESH | Brain Neoplasms/metabolism | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Chromosomes, Human, Pair 1 | - |
dc.subject.MESH | Chromosomes, Human, Pair 19 | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glioma/diagnosis* | - |
dc.subject.MESH | Glioma/genetics* | - |
dc.subject.MESH | Glioma/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Loss of Heterozygosity | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Clinical, histological, and immunohistochemical features predicting 1p/19q loss of heterozygosity in oligodendroglial tumors | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Tai Seung Kim | - |
dc.identifier.doi | 10.1007/s00401-005-1020-x | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A01071 | - |
dc.contributor.localId | A01183 | - |
dc.relation.journalcode | J00018 | - |
dc.identifier.eissn | 0942-0940 | - |
dc.identifier.pmid | 15920661 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00401-005-1020-x | - |
dc.subject.keyword | Oligodendroglioma | - |
dc.subject.keyword | Chromosomes human pair 1 | - |
dc.subject.keyword | Chromosomes human pair 19 | - |
dc.subject.keyword | Loss of heterozygosity | - |
dc.subject.keyword | Histology | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Tai Seung | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.citation.volume | 110 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 27 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | ACTA NEUROCHIRURGICA, Vol.110(1) : 27-38, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42742 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.