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Expression of cell adhesion molecules and chemokine receptors: Angioinvasiveness in nasal NK/T-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2017-10-26T06:30:21Z | - |
dc.date.available | 2017-10-26T06:30:21Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150889 | - |
dc.description.abstract | Sinonasal natural killer (NK)/T-cell lymphoma (NKTCL) is closely associated with Epstein-Barr virus (EBV) infection and expresses latent membrane protein (LMP)-1 and EB nuclear antigen (EBNA)-1, i.e., latency II of EBV infection. Angioinvasion by neoplastic cells is a characteristic feature of NKTCL, but its mechanism is unknown. To elucidate the molecular mechanism of angio-invasiveness in NKTCL, expression of cell adhesion molecules and chemokine receptors at mRNA and protein levels was examined using real-time PCR and immunohistochemistry in 17 NKTCL together with 10 diffuse large B-cell lymphoma (DLBL) and 9 non-neoplastic nasal mucosa as controls. EBV DNA was detected in 14 of 16 NKTCL examined, and 7 of these 14 expressed LMP-1. mRNA expression levels of integrin subunits α4, αL, αM, and β2 were significantly higher in NKTCL than non-neoplastic controls. Integrin subunits α2 and αM were expressed at a significantly higher level in NKTCL with angioinvasion than those without. Expression level of αM was significantly higher in 7 cases of NKTCL with LMP-1 expression than 7 without. Immunohistochemistry showed expression of these molecules in NKTCL cells. These findings suggest that EBV infection might be involved in the pathogenesis of angioinvasion of NKTCL through up-regulation of αM by LMP-1. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | D.A. Spandidos | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antigens, Viral/chemistry | - |
dc.subject.MESH | Cell Adhesion | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | DNA Primers/chemistry | - |
dc.subject.MESH | DNA, Complementary/metabolism | - |
dc.subject.MESH | Epstein-Barr Virus Nuclear Antigens/biosynthesis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Killer Cells, Natural/pathology* | - |
dc.subject.MESH | Lymphoma, T-Cell/metabolism* | - |
dc.subject.MESH | Lymphoma, T-Cell/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | Nasal Mucosa/pathology | - |
dc.subject.MESH | Neovascularization, Pathologic* | - |
dc.subject.MESH | RNA/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Receptors, Chemokine/biosynthesis* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Up-Regulation | - |
dc.subject.MESH | Viral Matrix Proteins/biosynthesis | - |
dc.subject.MESH | Viral Proteins/chemistry | - |
dc.subject.MESH | Virus Latency | - |
dc.title | Expression of cell adhesion molecules and chemokine receptors: Angioinvasiveness in nasal NK/T-cell lymphoma | - |
dc.type | Article | - |
dc.publisher.location | Greece | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Angen Liu | - |
dc.contributor.googleauthor | Shin-ichi Nakatsuka | - |
dc.contributor.googleauthor | Woo-Ick Yang | - |
dc.contributor.googleauthor | Shizuo Kojya | - |
dc.contributor.googleauthor | Katsuyuki Aozasa | - |
dc.identifier.doi | OAK-2005-03918 | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 15756432 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/13/4/613 | - |
dc.subject.keyword | 15756432 | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 613 | - |
dc.citation.endPage | 620 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.13(4) : 613-620, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42733 | - |
dc.type.rims | ART | - |
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