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Bone formation in calvarial defects of Sprague-Dawley rats by transplantation of calcium phosphate glass

Authors
 Hyun-Ju Moon  ;  Kyoung-Nam Kim  ;  Kwang-Mahn Kim  ;  Seong-Ho Choi  ;  Chong-Kwan Kim  ;  Kee-Deog Kim  ;  Racquel Z. LeGeros  ;  Yong-Keun Lee 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.74A(3) : 497-502, 2005 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 
ISSN
 1549-3296 
Issue Date
2005
MeSH
bone regeneration ; calcium phosphate glass ; calvarial defect ; Sprague‐Dawley rat
Keywords
bone regeneration ; calcium phosphate glass ; calvarial defect ; Sprague‐Dawley rat
Abstract
The purpose of this study was to investigate the bone-regenerative effect of calcium phosphate glass in vivo. We prepared amorphous calcium phosphate glass powder having a mean particle size of 400 μm in the system CaO-CaF2-P2O5-MgO-ZnO. Calvarial critical-sized defects (8 mm) were created in 60 male Sprague-Dawley rats. The animals were divided into an experimental group and control group of 30 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As a control, the defect was left empty. The rats were sacrificed 2, 4, or 8 weeks postsurgery, and the results evaluated using radiodensitometric and histological studies; they were also examined histomorphometrically. When the calcium phosphate glass powders with 400-μm particles were grafted, the defects were nearly completely filled with new-formed bone in a clean healing condition after 8 weeks. It was observed that the prepared calcium phosphate glass enhanced new bone formation in the calvarial defect of Sprague-Dawley rats and could be expected to have potential for use as a hard tissue regeneration material.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.30408/abstract
DOI
10.1002/jbm.a.30408
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Kim, Kee Deog(김기덕) ORCID logo https://orcid.org/0000-0003-3055-5130
Kim, Chong Kwan(김종관)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150877
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