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Papillary Thyroid Carcinoma Associated with Familial Adenomatous Polyposis: Molecular Analysis of Pathogenesis in a Familyand Review of the Literature

DC FieldValueLanguage
dc.contributor.author신성재-
dc.contributor.author이시훈-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author홍순원-
dc.date.accessioned2017-10-26T06:22:18Z-
dc.date.available2017-10-26T06:22:18Z-
dc.date.issued2005-
dc.identifier.issn0918-8959-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150844-
dc.description.abstractWe found a case of a papillary thyroid carcinoma that was accompanied by a familial adenomatous polyposis (FAP) in a 29-year-old female. She had hundreds of adenomas inside the entire colon and a congenital hypertrophy of the retinal pigmented epithelium (CHRPE). The patient underwent a total thyroidectomy and a central compartment neck node dissection. Gross examination of the thyroid identified two solid and cystic lesions. The pathological finding of thyroid cancer revealed a mixture of a peculiar nuclear clearing, cribriform, morula formation, trabecular and papillary pattern. The patient's brother had undergone a total colectomy due to FAP at the age of 25. Genetic analyses of the patient's family members revealed that she and her brother had the same germline mutation, in which five nucleotides (AAAGA) were deleted from codon 1309 of the adenomatous polyposis coli (APC) gene exon 15. Strong and frequent immunoreactivities of β-catenin and p53 were evident in the tumor tissue. At the time of writing, a preventive colectomy was still under consideration for the patient. Genetic counseling was given to the other family members, who were not attacked by this disease, in order to allay their fears of cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJapan Endocrine Society-
dc.relation.isPartOfEndocrine Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePapillary Thyroid Carcinoma Associated with Familial Adenomatous Polyposis: Molecular Analysis of Pathogenesis in a Familyand Review of the Literature-
dc.typeArticle-
dc.publisher.locationJapan-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSihoon LEE-
dc.contributor.googleauthorSoon Won HONG-
dc.contributor.googleauthorSung Jae SHIN-
dc.contributor.googleauthorYoo Mee KIM-
dc.contributor.googleauthorYumie RHEE-
dc.contributor.googleauthorBu Il JEON-
dc.contributor.googleauthorWoo Chul MOON-
dc.contributor.googleauthorMyung Ryurl OH-
dc.contributor.googleauthorSung-Kil LIM-
dc.identifier.doi10.1507/endocrj.51.317-
dc.contributor.localIdA02113-
dc.contributor.localIdA02942-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ00769-
dc.identifier.eissn1348-4540-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.alternativeNameLee, Si Hoon-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameHong, Soon Won-
dc.citation.volume51-
dc.citation.number3-
dc.citation.startPage317-
dc.citation.endPage323-
dc.identifier.bibliographicCitationEndocrine Journal, Vol.51(3) : 317-323, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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