Cited 10 times in
Structure and function of the potent cyclic and linear melanocortin analogues
DC Field | Value | Language |
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dc.contributor.author | 이창헌 | - |
dc.contributor.author | 임승길 | - |
dc.date.accessioned | 2017-10-26T06:20:02Z | - |
dc.date.available | 2017-10-26T06:20:02Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1047-8477 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150807 | - |
dc.description.abstract | The MC3R and MC4R proteins comprise two melanocortin receptor subtypes that are involved in obesity, with each protein displaying a unique mechanism of action. To enable the design of a selective drug candidate, the solution structures of four peptidyl analogues of the melanocyte stimulating hormones, NDP-MSH, NDP-MSH(4-10) and two cyclic forms ([C5,C10]NDP-MSH(5-10), [C5,C10]NDP-MSH(5-11)), were characterized by two-dimensional nuclear magnetic resonance (NMR) spectroscopy and simulated annealing calculations. Using data from c-AMP assays in combination with structural analysis of melanocortin receptor/ligand models, we conclude that a lysine residue at the C-terminus of the His-Phe-Arg-Trp core sequence of melanocortin hormone is an important determinant for receptor selectivity in the both cyclic and linear MSH analogues. Our results suggest that side-chain orientation and charge-charge interactions with the ligand molecule play critical roles in receptor selectivity, whereas the overall backbone conformation or turn type contributes mainly to receptor binding. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | JOURNAL OF STRUCTURAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Melanocortin | - |
dc.subject.MESH | Nuclear magnetic resonance | - |
dc.subject.MESH | Melanocortin receptor | - |
dc.subject.MESH | NDP-MSH | - |
dc.title | Structure and function of the potent cyclic and linear melanocortin analogues | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Min-Kyu Cho | - |
dc.contributor.googleauthor | Chul-Jin Lee | - |
dc.contributor.googleauthor | Chang-Hun Lee | - |
dc.contributor.googleauthor | Song-Zhe Li | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.contributor.googleauthor | Ja-Hyun Baik | - |
dc.contributor.googleauthor | Weontae Lee | - |
dc.identifier.doi | 10.1016/j.jsb.2005.03.008 | - |
dc.contributor.localId | A03247 | - |
dc.contributor.localId | A03375 | - |
dc.relation.journalcode | J01760 | - |
dc.identifier.eissn | 1095-8657 | - |
dc.identifier.pmid | 10.1016/j.jsb.2005.03.008 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1047847705000754 | - |
dc.subject.keyword | Melanocortin | - |
dc.subject.keyword | Nuclear magnetic resonance | - |
dc.subject.keyword | Melanocortin receptor | - |
dc.subject.keyword | NDP-MSH | - |
dc.contributor.alternativeName | Lee, Chang Hun | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.citation.volume | 150 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 308 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STRUCTURAL BIOLOGY, Vol.150(3) : 300-308, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44755 | - |
dc.type.rims | ART | - |
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