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Alpha(2b)-아드레날린 수용체 Insertion/Deletion 유전자 다형성과 관동맥질환과의 연관성

Other Titles
 An Insertion/Deletion Polymorphism in the α2B-Adrenoceptor Gene is not a Genetic Risk Factor for Coronary Artery Disease in the Korean Population 
Authors
 최정란  ;  박찬미  ;  홍정애  ;  배수진  ;  엄상미  ;  조은영  ;  고영국  ;  박현영  ;  장양수 
Citation
 Korean Circulation Journal, Vol.35(3) : 215-220, 2005 
Journal Title
 Korean Circulation Journal 
ISSN
 1738-5520 
Issue Date
2005
Abstract
BACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects. SUBJECTS AND METHODS: The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (M:F=219:73) with CAD and 151 healthy control subjects (M:F=70:81) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital. RESULTS: In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group. CONCLUSION: The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
고영국(Ko, Young Guk) ORCID logo https://orcid.org/0000-0001-7748-5788
박찬미(Park, Chan Mi)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
조은영(Cho, Eun Young)
최정란(Choi, Jung Ran)
홍정애(Hong, Jeong Ae)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150730
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