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Serotonin transporter gene polymorphism and migraine in the Korean population

DC Field Value Language
dc.contributor.author김세주-
dc.contributor.author김우경-
dc.contributor.author김원주-
dc.contributor.author김찬형-
dc.contributor.author김현숙-
dc.contributor.author박효진-
dc.contributor.author이경열-
dc.contributor.author최영철-
dc.date.accessioned2017-10-26T06:09:55Z-
dc.date.available2017-10-26T06:09:55Z-
dc.date.issued2005-
dc.identifier.issn0017-8748-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150594-
dc.description.abstractOBJECTIVE: To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans. BACKGROUND: The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake. METHODS: This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l). RESULTS: The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects. CONCLUSIONS: A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfHEADACHE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMigraine Disorders/genetics*-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHSerotonin Plasma Membrane Transport Proteins/genetics*-
dc.titleSerotonin transporter gene polymorphism and migraine in the Korean population-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.departmentOthers-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorWoo-Kyung Kim-
dc.contributor.googleauthorHyun-Sook Kim-
dc.contributor.googleauthorWon-Joo Kim-
dc.contributor.googleauthorKyung-Yul Lee-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorChan-Hyung Kim-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorYoung-Chul Choi-
dc.identifier.doi10.1111/j.1526-4610.2005.05187.x-
dc.contributor.localIdA00604-
dc.contributor.localIdA00757-
dc.contributor.localIdA00771-
dc.contributor.localIdA01036-
dc.contributor.localIdA01117-
dc.contributor.localIdA01774-
dc.contributor.localIdA02648-
dc.contributor.localIdA04116-
dc.relation.journalcodeJ00964-
dc.identifier.eissn1526-4610-
dc.identifier.pmid16109120-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2005.05187.x/abstract-
dc.subject.keywordmigraine-
dc.subject.keywordserotonin transporter-
dc.subject.keywordserotonin transporter gene polymorphism-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameKim, Woo Kyung-
dc.contributor.alternativeNameKim, Won Joo-
dc.contributor.alternativeNameKim, Chan Hyung-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameLee, Kyung Yul-
dc.contributor.alternativeNameChoi, Young Chul-
dc.citation.volume45-
dc.citation.number8-
dc.citation.startPage1056-
dc.citation.endPage1060-
dc.identifier.bibliographicCitationHEADACHE, Vol.45(8) : 1056-1060, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid44167-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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