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Serotonin transporter gene polymorphism and migraine in the Korean population

 Woo-Kyung Kim  ;  Hyun-Sook Kim  ;  Won-Joo Kim  ;  Kyung-Yul Lee  ;  Hyojin Park  ;  Chan-Hyung Kim  ;  Se Joo Kim  ;  Young-Chul Choi 
 HEADACHE, Vol.45(8) : 1056-1060, 2005 
Journal Title
Issue Date
Adolescent ; Adult ; Asian Continental Ancestry Group/genetics* ; Female ; Gene Frequency ; Genotype ; Humans ; Korea ; Male ; Middle Aged ; Migraine Disorders/genetics* ; Polymorphism, Genetic* ; Serotonin Plasma Membrane Transport Proteins/genetics*
migraine ; serotonin transporter ; serotonin transporter gene polymorphism
OBJECTIVE: To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans.
BACKGROUND: The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake.
METHODS: This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l).
RESULTS: The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects.
CONCLUSIONS: A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Woo Kyung(김우경)
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Kim, Chan Hyung(김찬형)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
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