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Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome

DC Field Value Language
dc.contributor.author김지홍-
dc.contributor.author이재승-
dc.contributor.author정현주-
dc.date.accessioned2017-10-26T05:56:17Z-
dc.date.available2017-10-26T05:56:17Z-
dc.date.issued2005-
dc.identifier.issn0931-041X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150506-
dc.description.abstractTo evaluate the efficacy of cyclosporin A (CyA) for treating severe Henoch-Schönlein nephritis (HSN), seven patients with nephrotic syndrome, aged 3.9–13.8 years (mean 6.5 years), were analyzed retrospectively. Mean follow-up times were 5.5 years (range 2–9 years). All underwent renal biopsy before treatment, and follow-up renal biopsy was performed in six of the seven patients. All patients improved, with 24-h protein declining from a mean of 9.2 g/m2/day (range 1.5–16 g/m2/day) to 0.3 g/m2/day (range 0.03–1.2 g/m2/day) (p=0.016) and serum albumin increasing from a mean of 2.1 g/dl (range 1.5–2.4 g/dl) to 4.6 g/dl (range 3.5–5.3 g/dl) (p=0.016) after CyA therapy. The activity index decreased significantly at the second renal biopsies obtained at a mean interval of 11.7 months after the first (6.4±3.3 vs 3.5±1.2, p=0.042, respectively), while the chronicity index and the tubulointerstitial scores did not change. On the immunofluorescent findings at the second biopsies, the degree of deposits of immunoglobulins such as IgA, IgM, C3, and fibrinogen decreased in five of the six patients. Although this case series is without controls, our study suggests that CyA may be beneficial to a subset of HSN patients with nephrotic syndrome.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfPEDIATRIC NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCyclosporine/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHGlomerulonephritis/drug therapy*-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHNephrotic Syndrome/drug therapy-
dc.subject.MESHProteinuria/drug therapy-
dc.subject.MESHPurpura, Schoenlein-Henoch/complications*-
dc.subject.MESHPurpura, Schoenlein-Henoch/drug therapy*-
dc.subject.MESHPurpura, Schoenlein-Henoch/immunology-
dc.subject.MESHPurpura, Schoenlein-Henoch/pathology-
dc.subject.MESHRetrospective Studies-
dc.titleCyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorJee Min Park-
dc.contributor.googleauthorYoun Ho Shin-
dc.contributor.googleauthorJi Hong Kim-
dc.contributor.googleauthorPyung Kil Kim-
dc.contributor.googleauthorJae Seung Lee-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.identifier.doi10.1007/s00467-005-1864-2-
dc.contributor.localIdA01003-
dc.contributor.localIdA03076-
dc.contributor.localIdA03771-
dc.relation.journalcodeJ02488-
dc.identifier.eissn1432-198X-
dc.identifier.pmid15947993-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00467-005-1864-2-
dc.subject.keywordHenoch-Schönlein nephritis-
dc.subject.keywordCyclosporin A-
dc.subject.keywordNephrotic syndrome-
dc.subject.keywordActivity index-
dc.subject.keywordChronicity index-
dc.subject.keywordTubulointerstitial score-
dc.contributor.alternativeNameKim, Ji Hong-
dc.contributor.alternativeNameLee, Jae Seung-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.citation.volume20-
dc.citation.number8-
dc.citation.startPage1093-
dc.citation.endPage1097-
dc.identifier.bibliographicCitationPEDIATRIC NEPHROLOGY, Vol.20(8) : 1093-1097, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid42786-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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