Cited 49 times in
Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome
DC Field | Value | Language |
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dc.contributor.author | 김지홍 | - |
dc.contributor.author | 이재승 | - |
dc.contributor.author | 정현주 | - |
dc.date.accessioned | 2017-10-26T05:56:17Z | - |
dc.date.available | 2017-10-26T05:56:17Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0931-041X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150506 | - |
dc.description.abstract | To evaluate the efficacy of cyclosporin A (CyA) for treating severe Henoch-Schönlein nephritis (HSN), seven patients with nephrotic syndrome, aged 3.9–13.8 years (mean 6.5 years), were analyzed retrospectively. Mean follow-up times were 5.5 years (range 2–9 years). All underwent renal biopsy before treatment, and follow-up renal biopsy was performed in six of the seven patients. All patients improved, with 24-h protein declining from a mean of 9.2 g/m2/day (range 1.5–16 g/m2/day) to 0.3 g/m2/day (range 0.03–1.2 g/m2/day) (p=0.016) and serum albumin increasing from a mean of 2.1 g/dl (range 1.5–2.4 g/dl) to 4.6 g/dl (range 3.5–5.3 g/dl) (p=0.016) after CyA therapy. The activity index decreased significantly at the second renal biopsies obtained at a mean interval of 11.7 months after the first (6.4±3.3 vs 3.5±1.2, p=0.042, respectively), while the chronicity index and the tubulointerstitial scores did not change. On the immunofluorescent findings at the second biopsies, the degree of deposits of immunoglobulins such as IgA, IgM, C3, and fibrinogen decreased in five of the six patients. Although this case series is without controls, our study suggests that CyA may be beneficial to a subset of HSN patients with nephrotic syndrome. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | PEDIATRIC NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cyclosporine/therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerulonephritis/drug therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nephrotic Syndrome/drug therapy | - |
dc.subject.MESH | Proteinuria/drug therapy | - |
dc.subject.MESH | Purpura, Schoenlein-Henoch/complications* | - |
dc.subject.MESH | Purpura, Schoenlein-Henoch/drug therapy* | - |
dc.subject.MESH | Purpura, Schoenlein-Henoch/immunology | - |
dc.subject.MESH | Purpura, Schoenlein-Henoch/pathology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Jee Min Park | - |
dc.contributor.googleauthor | Youn Ho Shin | - |
dc.contributor.googleauthor | Ji Hong Kim | - |
dc.contributor.googleauthor | Pyung Kil Kim | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.identifier.doi | 10.1007/s00467-005-1864-2 | - |
dc.contributor.localId | A01003 | - |
dc.contributor.localId | A03076 | - |
dc.contributor.localId | A03771 | - |
dc.relation.journalcode | J02488 | - |
dc.identifier.eissn | 1432-198X | - |
dc.identifier.pmid | 15947993 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00467-005-1864-2 | - |
dc.subject.keyword | Henoch-Schönlein nephritis | - |
dc.subject.keyword | Cyclosporin A | - |
dc.subject.keyword | Nephrotic syndrome | - |
dc.subject.keyword | Activity index | - |
dc.subject.keyword | Chronicity index | - |
dc.subject.keyword | Tubulointerstitial score | - |
dc.contributor.alternativeName | Kim, Ji Hong | - |
dc.contributor.alternativeName | Lee, Jae Seung | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.citation.volume | 20 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1093 | - |
dc.citation.endPage | 1097 | - |
dc.identifier.bibliographicCitation | PEDIATRIC NEPHROLOGY, Vol.20(8) : 1093-1097, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42786 | - |
dc.type.rims | ART | - |
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