Cited 15 times in
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors
DC Field | Value | Language |
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dc.contributor.author | 김대준 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 박인규 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 정경영 | - |
dc.date.accessioned | 2017-10-26T05:56:11Z | - |
dc.date.available | 2017-10-26T05:56:11Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1010-7940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150500 | - |
dc.description.abstract | OBJECTIVE: Neurotrophins are known to exert a variety of pleiotropic responses in different target tissues, but little is known about their effect on thymic epithelial tumors. Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. METHODS: The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75(NTR)) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. The pattern of expression was analyzed according to the WHO classification, and survival outcomes were estimated. RESULTS: Thymic tumors were classified as type A (n=6), AB (n=21), B1 (n=15), B2 (n=24), B3 (n=22) or C (n=11). All tumors, except one type C thymoma, demonstrated cytoplasmic Trk-A immunostaining, and no thymic tumors showed Trk-B or Trk-C immunoreactivity. p75(NTR) immunostaining demonstrated characteristic patterns according to the WHO subtypes of thymomas. All type A and type AB thymomas showed p75(NTR) immunoreactivity, except one type A tumor. The expression of p75(NTR) was negative in 6 patients (40%) with type B1 thymomas, 19 patients (79.2%) with type B2 thymomas, 17 patients (77.3%) with type B3 thymomas and 10 patients (90.9%) with type C thymomas. Tumor-related survival at 5 and 10 years was 95.5 and 89.5%, respectively, in p75(NTR)-positive thymomas and 82.8 and 77.2%, respectively, in p75(NTR)-negative thymomas; however, the differences were not statistically significant (P=0.14). CONCLUSIONS: Among the neurotrophin receptors examined, the pattern of p75(NTR) expression closely correlated with the WHO subtypes of thymomas. Further study of p75(NTR) expression may aid in understanding the biology of thymic epithelial tumors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins/analysis | - |
dc.subject.MESH | Nerve Tissue Proteins/analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptor, trkA/analysis | - |
dc.subject.MESH | Receptor, trkB/analysis | - |
dc.subject.MESH | Receptor, trkC/analysis | - |
dc.subject.MESH | Receptors, Growth Factor/analysis | - |
dc.subject.MESH | Receptors, Nerve Growth Factor/analysis* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Thymoma/chemistry* | - |
dc.subject.MESH | Thymoma/pathology | - |
dc.subject.MESH | Thymoma/surgery | - |
dc.subject.MESH | Thymus Gland/metabolism | - |
dc.subject.MESH | Thymus Gland/pathology | - |
dc.subject.MESH | Thymus Neoplasms/chemistry* | - |
dc.subject.MESH | Thymus Neoplasms/pathology | - |
dc.subject.MESH | Thymus Neoplasms/surgery | - |
dc.title | Expression of neurotrophin receptors in surgically resected thymic epithelial tumors | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Woo-Ick Yang | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | In-Kyu Park | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.identifier.doi | 10.1016/j.ejcts.2005.06.034 | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A01625 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03571 | - |
dc.relation.journalcode | J00811 | - |
dc.identifier.eissn | 1873-734X | - |
dc.identifier.pmid | 16125946 | - |
dc.identifier.url | http://ejcts.oxfordjournals.org/content/28/4/611.long | - |
dc.subject.keyword | Thymoma | - |
dc.subject.keyword | Surgery | - |
dc.subject.keyword | Receptors | - |
dc.subject.keyword | Pathology | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Park, In Kyu | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 611 | - |
dc.citation.endPage | 616 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol.28(4) : 611-616, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42780 | - |
dc.type.rims | ART | - |
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