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Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells

Other Titles
 Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells 
Authors
 Youn-Hee Choi  ;  Si-Hwan Ko  ;  Se Jong Kim  ;  Won-Young Lee  ;  Jeon Han Park  ;  Jae Myun Lee 
Citation
 Biochemical and Biophysical Research Communications, Vol.337(4) : 1059-1064, 2005 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2005
Abstract
To examine the photodynamic therapy (PDT) effect on adipocytes, we investigated whether PDT using DH-I-180-3, a new synthetic lipophilic photosensitizer, induced cell death of both undifferentiated and differentiated 3T3-L1. 3T3-L1 pre-adipocytes were differentiated into adipocytes in the culture medium containing pantothenate, insulin, dexamethasone, isobutylmethylxanthine, and troglitazone. PDT was applied to both undifferentiated and differentiated 3T3-L1. Photosensitizer uptake in fat cells was determined by measuring its mean fluorescence intensity. DH-I-180-3 mediated effectively PDT-induced cell death of both pre-adipocytes and adipocytes. And the photosensitizer was accumulated more rapidly in 3T3-L1 adipocytes, compared with other cancer cell lines. These results demonstrate that PDT is a potent cell death inducer in pre-adipocytes and adipocytes. Thus, PDT with DH-I-180-3 may be applied for a new therapeutic modality for obesity treatment.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X05021765
DOI
10.1016/j.bbrc.2005.09.151
Appears in Collections:
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
고시환(Ko, Si Hwan)
김세종(Kim, Se Jong)
박전한(Park, Jeon Han) ORCID logo https://orcid.org/0000-0001-9604-3205
이원영(Lee, Won Young)
이재면(Lee, Jae Myun) ORCID logo https://orcid.org/0000-0002-5273-3113
최윤희(Choi, Youn Hee)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150014
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