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Berberine Inhibits the Production of Lysophosphatidylcholine-induced Reactive Oxygen Species and the ERK1/2 Pathway in Vascular Smooth Muscle Cells
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2017-09-29T06:32:08Z | - |
dc.date.available | 2017-09-29T06:32:08Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149908 | - |
dc.description.abstract | Lysophosphatidylcholine (lysoPC) induces vascular smooth muscle cell (VSMC) proliferation and migration, which has been proposed to initiate the intimal thickening in coronary atherosclerotic lesions. Berberine is an alkaloid in Berberis aquifolium and many other plants. Recently, it has been shown to have beneficial effects on the cardiovascular system, such as anti-hyperglycemic and cholesterol-lowering activity. In this study, we investigated its effects on lysoPC-induced VSMC proliferation and migration. Berberine inhibited lysoPC-induced DNA synthesis and cell proliferation in VSMCs, as well as migration of the lysoPC-stimulated VSMCs. It also inhibited the activation of extracellular signal-regulated kinases (ERKs) and reduced transcription factor AP-1 activity and the lysoPC-induced increases in intracellular reactive oxygen species (ROS). These results indicate that the inhibitory effects of berberine on lysoPC-stimulated VSMC proliferation and migration are attributable to inhibition of ROS generation and hence of activation of the ERK1/2 pathway. This suggests that berberine has potential in the prevention of atherosclerosis and restenosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aorta/cytology | - |
dc.subject.MESH | Aorta/drug effects | - |
dc.subject.MESH | Aorta/metabolism | - |
dc.subject.MESH | Berberine/pharmacology* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Movement/drug effects | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Lysophosphatidylcholines/pharmacology* | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 1/antagonists & inhibitors | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 1/metabolism* | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 3/antagonists & inhibitors | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 3/metabolism* | - |
dc.subject.MESH | Muscle, Smooth, Vascular*/cytology | - |
dc.subject.MESH | Muscle, Smooth, Vascular*/drug effects | - |
dc.subject.MESH | Muscle, Smooth, Vascular*/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species/antagonists & inhibitors | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Signal Transduction/drug effects* | - |
dc.subject.MESH | Thymidine/metabolism | - |
dc.subject.MESH | Transcription Factor AP-1/metabolism | - |
dc.title | Berberine Inhibits the Production of Lysophosphatidylcholine-induced Reactive Oxygen Species and the ERK1/2 Pathway in Vascular Smooth Muscle Cells | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Bong-Jun Cho | - |
dc.contributor.googleauthor | Eun Kyoung Im | - |
dc.contributor.googleauthor | Jun Hye Kwon | - |
dc.contributor.googleauthor | Kyung-Hye Lee | - |
dc.contributor.googleauthor | Hye-Jin Shin | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Ji Hyung Chung | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | OAK-2005-06688 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 16404160 | - |
dc.subject.keyword | 16404160 | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 429 | - |
dc.citation.endPage | 434 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.20(3) : 429-434, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 41999 | - |
dc.type.rims | ART | - |
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