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Mesenchymal stem cells and its derived matrix metalloproteinase-2 enhance degradation of extracellular α-synuclein aggregates in parkinsonian models
DC Field | Value | Language |
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dc.contributor.author | 오세희 | - |
dc.date.accessioned | 2017-07-11T16:10:22Z | - |
dc.date.available | 2017-07-11T16:10:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149137 | - |
dc.description | Dept. of Medical Science/박사 | - |
dc.description.abstract | Ample evidence has suggested that extracellular α-synuclein aggregates would play key roles in the pathogenesis and progression of Parkinsonian disorders (PD). In the present study, I investigated whether mesenchymal stem cells (MSCs) and their derived soluble factors could exert neuroprotective effects via proteolysis of extracellular α-synuclein. When preformed α-synuclein aggregates were incubated with MSC-conditioned medium, α-synuclein aggregates were disassembled and insoluble and oligomeric forms of α-synuclein were markedly decreased, thus leading to a significant increase in neuronal viability. In an animal study, MSC or MSC-conditioned medium treatment decreased the expression of α-synuclein oligomers and the induction of pathogenic α-synuclein with an attenuation of apoptotic cell death signaling. Furthermore, this study was identified that matrix metalloproteinase-2 (MMP-2), a soluble factor derived from MSCs, played an important role in the degradation of extracellular α-synuclein. this study was demonstrated that MSC and its derived MMP-2 exert neuroprotective properties through proteolysis of aggregated α-synuclein in PD-related microenvironments. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Mesenchymal stem cells and its derived matrix metalloproteinase-2 enhance degradation of extracellular α-synuclein aggregates in parkinsonian models | - |
dc.title.alternative | 파킨슨 질환에서 중간엽 줄기세포와 중간엽 줄기세포 유래 단백질 분해효소-2에 의한 알파시누클린 응집의 분해 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Oh, Se Hee | - |
dc.type.local | Dissertation | - |
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