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Effect of different hydroxyapatite : β-tricalcium phosphate ratios on the osteoconductivity and dimensional stability of biphasic calcium phosphate in the rabbit sinus model

Authors
 임현창 
Issue Date
2016
Description
치과대학/박사
Abstract
Objective: The present study compared the osteoconductivity and the volume stability of biphasic calcium phosphate (BCP) with a high versus a low ratio of beta tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA; i.e., 70:30 vs. 30:70) in the rabbit sinus model.



Material and Methods: Experiement1-short and middle term evaluation; Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5-3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA:β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (i.e., 70:30; TCP70) and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (i.e., 30:70; TCP30). The animals were sacrificed after 2 (n=4) or 8 weeks (n=4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography (micro-CT). Experiement2- late term evaluation; Experimental protocol was followed expertment1. In five rabbits, sinus augmentation was performed. Calcein green was injected five days before euthanizing. The animals were euthanized 16 weeks postsurgery.



Results: Experiement1; The total augmented volume (TV) in micro-CT, and the area of new bone (NA) and bone-to-material contact (%NPC) in histologic section did not differ significantly between the two groups at 2 and 8 weeks of healing. The augmented volume did not show significant decrease between 2 and 8 weeks. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. Larger amount of multinucleated giant cell was observed in the TCP70 group at both weeks. Experiement2; Micro-CT analysis revealed that TV and new bone volume (NV) did not show statistical difference between both groups, but the resorption of materials was statistically higher in the TCP70 group than the TCP30 group. Histomorphometrically, TA, NA and the area of residual material (RA), and %NPC did not differ significantly. Trabecular thickness, number and separation were not statistically significant between both groups. Fluorescence with calcein green showed no notable difference between both groups.



Conclusion: Within limitation of this study, the BCPs with HA: β-TCP = 3:7 and 7:3 were demonstrated to be comparably effective in maintaining volume stability and bone formation.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Others (기타) > 3. Dissertation
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/148951
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