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Serum interleukin-27 expression in patients with myasthenia gravis
DC Field | Value | Language |
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dc.contributor.author | 정하늘 | - |
dc.date.accessioned | 2017-07-07T16:10:35Z | - |
dc.date.available | 2017-07-07T16:10:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/148771 | - |
dc.description | 의과대학/석사 | - |
dc.description.abstract | Myasthenia gravis (MG) is a well-characterized autoimmune disease directed at the postsynaptic acetylcholine receptor (AChR) or end plate of the neuromuscular junction. Interferon-γ, tumor necrosis factor-α, interleukin-17, and thymic abnormality are related to the pathogenesis and immunoregulation of MG. IL-27 is a new cytokine that promote T helper 1 (Th1) cells differentiation, inhibit the differentiation and function of T helper 17 (Th17), T helper 2 (Th2) cells. In addition, IL-27 is critical for the function of T follicular helper cells and for germinal center responses. The purpose of this study was to assess the role of IL-27 in human MG pathogenesis. We determined IL-27 levels in patients with MG (n=32) compared to healthy controls (n=50). Serum IL-27 levels of patients with MG and controls were 35.947 (23.044-112.949) pg/mL and 19.885 (7.795-118.372) pg/mL, respectively which were significantly higher in MG patients (p=0.019). Furthermore, Serum IL-27 levels were significantly higher in early onset MG patients (classified as patients with age of onset < 50) than in late onset MG patients (p=0.022): 52.809 (25.901-252.894) pg/mL and 26.068 (17.773-36.270) pg/mL, respectively. This study suggests the possibility that IL-27 might contribute to MG pathogenesis or immunoregulation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format | application/pdf | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serum interleukin-27 expression in patients with myasthenia gravis | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Jeong, Ha-Neul | - |
dc.type.local | Thesis | - |
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