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Clinical implication of triple-negative breast cancer in the era of breast-conserving therapy
DC Field | Value | Language |
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dc.contributor.author | 김상화 | - |
dc.date.accessioned | 2017-07-07T16:10:19Z | - |
dc.date.available | 2017-07-07T16:10:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/148621 | - |
dc.description | 의과대학/석사 | - |
dc.description.abstract | Background and Objectives : The optimum local surgical strategy regarding Breast-Conserving Therapy (BCT) for Triple-Negative Breast Cancer (TNBC) is controversial. We evaluated the clinical outcomes of BCT in women with TNBC compared to those without TNBC, using a large, single center cohort. Methods : We performed a retrospective analysis of 1533 women (TNBC n=321; non-TNBC n=1212) who underwent BCT for primary breast cancer between 2000 and 2010. Clinicopathological characteristics, locoregional recurrence-free survival (LRFS), and overall survival (OS) were analyzed. Results : Tumors from the TNBC group had higher T stage (T2 37.4% vs. 21.0%, p<0.001), lower N stage (N0 86.9% vs. 75.5%, p<0.001), and higher histologic grade (Grade III 66.8% vs. 15.4%, p<0.001) versus the non-TNBC group. There were no differences in 5-year LRFS rates between the TNBC and non-TNBC groups (98.7% vs. 97.8%, p=0.63). The non-TNBC group showed a slightly better 5-year OS than the TNBC group, but the difference was not significant (96.2% vs. 97.3%, p=0.72). In multivariate analyses, TNBC was not associated with poor clinical outcomes in terms of LRFS and OS (HR for LRFS=0.37, 95% CI=0.10-1.31, HR for OS=1.03, 95% CI=0.31-3.39). Conclusions : TNBC patients who underwent BCT showed relatively low locoregional recurrence. BCT is an acceptable surgical approach in selected patients with TNBC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical implication of triple-negative breast cancer in the era of breast-conserving therapy | - |
dc.title.alternative | 유방보존술을 시행한 유방암환자에서 삼중음성유방암의 임상적 영향 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.localId | A00533 | - |
dc.contributor.alternativeName | Kim, Sanghwa | - |
dc.contributor.affiliatedAuthor | 김상화 | - |
dc.type.local | Thesis | - |
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