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Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease
DC Field | Value | Language |
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dc.contributor.author | 신명헌 | - |
dc.date.accessioned | 2017-05-08T08:01:30Z | - |
dc.date.available | 2017-05-08T08:01:30Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147678 | - |
dc.description.abstract | Eosinophil degranulation is considered to be a key effector function for the killing of helminthic worms and tissue inflammation at worm-infected lesion sites. However, relatively little data are available with regard to eosinophil response after stimulation with worm-secreted products which contain a large quantity of cysteine proteases. In this study, we attempted to determine whether the degranulation of human eosinophils could be induced by the direct stimulation of the excretory-secretory products (ESP) of Paragonimus westermani, which causes pulmonary paragonimiasis in human beings. Incubation of eosinophils for 3 hr with Paragonimus-secreted products resulted in marked degranulation, as evidenced by the release of eosinophil-derived neurotoxin (EDN) in the culture supernatants. Moreover, superoxide anion was produced by eosinophils after stimulation of the ESP. The ESP-induced EDN release was found to be significantly inhibited when the ESP was pretreated with protease inhibitor cocktail or the cysteine protease inhibitor, E-64. These findings suggest that human eosinophils become degranulated in response to P. westermani-secreted proteases, which may contribute to in vivo tissue inflammation around the worms. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~11 | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society for Parasitology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Paragonimus westermani | - |
dc.subject.MESH | excretory-secretory products (ESP) | - |
dc.subject.MESH | cysteine protease | - |
dc.subject.MESH | eosinophils | - |
dc.subject.MESH | degranulation | - |
dc.title | Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Tropica Medicine (열대의학교실) | - |
dc.contributor.googleauthor | Myeong Heon Shin | - |
dc.contributor.googleauthor | Young-Bae Chung | - |
dc.contributor.googleauthor | Hirohito Kita | - |
dc.identifier.doi | 10.3347/kjp.2005.43.1.33 | - |
dc.contributor.localId | A02099 | - |
dc.relation.journalcode | J01957 | - |
dc.identifier.eissn | 1738-0006 | - |
dc.identifier.pmid | 10.3347/kjp.2005.43.1.33 | - |
dc.subject.keyword | Paragonimus westermani | - |
dc.subject.keyword | excretory-secretory products (ESP) | - |
dc.subject.keyword | cysteine protease | - |
dc.subject.keyword | eosinophils | - |
dc.subject.keyword | degranulation | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, Vol.43(1) : 1-11, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 45221 | - |
dc.type.rims | ART | - |
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