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Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder

Authors
 Heon-Jeong Lee  ;  Min-Soo Lee  ;  Rhee-Hun Kang  ;  Hyun Kim  ;  Soon-Duck Kim  ;  Baik-Seok Kee  ;  Young Hoon Kim  ;  Yong-Ku Kim  ;  Jung Bum Kim  ;  Byung Kil Yeon  ;  Kang Seob Oh  ;  Byung-Hoon Oh  ;  Jin-Sang Yoon  ;  Chul Lee  ;  Han Yong Jung  ;  Ik-Seung Chee  ;  In Ho Paik 
Citation
 DEPRESSION AND ANXIETY, Vol.21(3) : 135-139, 2005 
Journal Title
 DEPRESSION AND ANXIETY 
ISSN
 1091-4269 
Issue Date
2005
MeSH
Adult ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Polymerase Chain Reaction ; Polymorphism, Genetic/genetics* ; Promoter Regions, Genetic/genetics* ; Promoter Regions, Genetic/physiology ; Serotonin Plasma Membrane Transport Proteins/genetics* ; Serotonin Plasma Membrane Transport Proteins/physiology ; Stress Disorders, Post-Traumatic/genetics* ; Stress Disorders, Post-Traumatic/physiopathology*
Keywords
PTSD ; serotonin transporter ; polymorphism
Abstract
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin-transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/da.20064/abstract
DOI
10.1002/da.20064
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147606
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