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Three-dimensional visualization and quantitative analysis of cervical cell nuclei with confocal laser scanning microscopy
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2017-05-04T07:37:36Z | - |
dc.date.available | 2017-05-04T07:37:36Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0884-6812 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147555 | - |
dc.description.abstract | Objective: To develop a method for the acquisition and processing of 3-dimensional images based on confocal laser scanning microscopy for the purpose of 3-dimensional visualization and quantitative analysis of cell nuclei. Study Design: A contour-based surface rendering method was used, and volume rendering was implemented according to the basic volume rendering pipeline. To extract quantitative features, a 3-dimensional labeling method based on slice information was used. After applying the labeling algorithm, the measurements for 3-dimensional quantitative analysis of nuclei were extracted: nuclear volume, surface area and spherical shape factor. We compared the 3-dimensional features of normal and abnormal cervical cell nuclei. Results: Comparison of the size of 3-dimensional cervical cell nuclei between normal and abnormal revealed a statistically significant difference. The proposed method could overcome the limitation inherent in 2-dimensional analysis and could become a way of improving the accuracy and reproducibility of quantification of cell nuclei. Conclusion: Three-dimensional visualization and quantification of cell nuclei provide valuable medical information that can lead to a more objective diagnosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Science Printers and Publishers | - |
dc.relation.isPartOf | ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Algorithms | - |
dc.subject.MESH | Cell Nucleus/pathology* | - |
dc.subject.MESH | Cervix Uteri/pathology* | - |
dc.subject.MESH | Data Interpretation, Statistical | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imaging, Three-Dimensional/methods* | - |
dc.subject.MESH | Laser Scanning Cytometry/methods* | - |
dc.subject.MESH | Microscopy, Confocal/methods | - |
dc.subject.MESH | Software | - |
dc.title | Three-dimensional visualization and quantitative analysis of cervical cell nuclei with confocal laser scanning microscopy | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hyun-Ju Choi | - |
dc.contributor.googleauthor | Ik-Hwan Choi | - |
dc.contributor.googleauthor | Tae-Yun Kim | - |
dc.contributor.googleauthor | Nam-Hoon Cho | - |
dc.contributor.googleauthor | Heung-Kook Choi | - |
dc.identifier.doi | OAK-2005-03193 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J00133 | - |
dc.relation.journalsince | 1985~2012 | - |
dc.relation.journalafter | 2013~ Analytical and Quantitative Cytopathology and Histopathology | - |
dc.identifier.pmid | 16121640 | - |
dc.identifier.url | http://www.aqch.com/toc/auto_abstract.php?id=22120 | - |
dc.subject.keyword | quantitative evaluation | - |
dc.subject.keyword | cervix | - |
dc.subject.keyword | cell nucleus | - |
dc.subject.keyword | confocal laser scanning microscopy | - |
dc.subject.keyword | 3-dimensional visualization | - |
dc.subject.keyword | 3-dimensional feature extraction | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 174 | - |
dc.citation.endPage | 180 | - |
dc.identifier.bibliographicCitation | ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, Vol.27(3) : 174-180, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40329 | - |
dc.type.rims | ART | - |
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