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Alternative Usages of Multiple Promoters of the Acetyl-CoA Carboxylase β Gene Are Related to Differential Transcriptional Regulation in Human and Rodent Tissues

DC FieldValueLanguage
dc.contributor.author김경섭-
dc.contributor.author김종민-
dc.contributor.author박영년-
dc.contributor.author신순아-
dc.contributor.author안용호-
dc.contributor.author오소영-
dc.contributor.author윤사라-
dc.contributor.author이민영-
dc.date.accessioned2017-05-04T07:37:30Z-
dc.date.available2017-05-04T07:37:30Z-
dc.date.issued2005-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147554-
dc.description.abstractAcetyl-CoA carboxylase beta (ACCbeta) is a critical enzyme in the regulation of fatty acid oxidation and is dominantly expressed in the skeletal muscle, heart, and liver. It has been established that two promoters, P-I and P-II, control the transcription of the ACCbeta gene. However, the precise mechanism involved in controlling tissue-specific gene expression of ACCbeta is largely unknown yet. In this study we revealed that promoter P-I, active in the skeletal muscle and heart but not in the liver, could be activated by myogenic regulatory factors and retinoid X receptors in a synergistic manner. Moreover, P-I was also activated markedly by the cardiac-specific transcription factors, Csx/Nkx2.5 and GATA4. These results suggest that the proper stimulation of P-I by these tissue-specific transcription factors is important for the expression of ACCbeta according to the tissue types. In addition, CpG sites around human exon 1a transcribed by P-I are half-methylated in muscle but completely methylated in the liver, where P-I is absolutely inactive. In humans, the skeletal muscle uses P-II as well as P-I, whereas only P-I is active in rat skeletal muscle. The proximal myogenic regulatory factor-binding sites in human P-II, which are not conserved in rat P-II, might contribute to this difference in P-II usage between human and rat skeletal muscle. Hepatoma-derived cell lines primarily use another novel promoter located about 3 kilobases upstream of P-I, designated as P-O. This study is the first to explain the mechanisms underlying the differential regulation of ACCbeta gene expression between tissues in living organisms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5909~5916-
dc.languageEnglish-
dc.publisherAmerican Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfJOURNAL OF BIOLOGICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH5' Untranslated Regions/analysis-
dc.subject.MESH5' Untranslated Regions/genetics-
dc.subject.MESHAcetyl-CoA Carboxylase/genetics*-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHCell Line-
dc.subject.MESHConserved Sequence-
dc.subject.MESHCpG Islands/genetics-
dc.subject.MESHDNA-Binding Proteins/metabolism-
dc.subject.MESHDiet-
dc.subject.MESHExons/genetics-
dc.subject.MESHGATA4 Transcription Factor-
dc.subject.MESHGene Expression Regulation/drug effects-
dc.subject.MESHGene Expression Regulation/genetics*-
dc.subject.MESHHumans-
dc.subject.MESHLiver/drug effects-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMuscle, Skeletal/drug effects-
dc.subject.MESHMuscle, Skeletal/metabolism-
dc.subject.MESHMyocardium/metabolism-
dc.subject.MESHMyogenic Regulatory Factors/metabolism-
dc.subject.MESHOrgan Specificity-
dc.subject.MESHPromoter Regions, Genetic/genetics*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Retinoic Acid/metabolism-
dc.subject.MESHTranscription Factors/metabolism-
dc.subject.MESHTranscription Initiation Site-
dc.subject.MESHTranscription, Genetic/drug effects-
dc.subject.MESHTranscription, Genetic/genetics*-
dc.titleAlternative Usages of Multiple Promoters of the Acetyl-CoA Carboxylase β Gene Are Related to Differential Transcriptional Regulation in Human and Rodent Tissues-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorSo-Young Oh-
dc.contributor.googleauthorMin-Young Lee-
dc.contributor.googleauthorJong-Min Kim-
dc.contributor.googleauthorSarah Yoon-
dc.contributor.googleauthorSoonah Shin-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorYong-Ho Ahn-
dc.contributor.googleauthorKyung-Sup Kim-
dc.identifier.doi10.1074/jbc.M409037200-
dc.contributor.localIdA00297-
dc.contributor.localIdA00917-
dc.contributor.localIdA01563-
dc.contributor.localIdA02119-
dc.contributor.localIdA02249-
dc.contributor.localIdA02381-
dc.contributor.localIdA02557-
dc.contributor.localIdA02783-
dc.relation.journalcodeJ01258-
dc.identifier.eissn1083-351X-
dc.identifier.pmid15590647-
dc.subject.keyword15590647-
dc.contributor.alternativeNameKim, Kyung Sup-
dc.contributor.alternativeNameKim, Jong Min-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameShin, Soonah-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.alternativeNameOh, So Young-
dc.contributor.alternativeNameYoon, Sa Rah-
dc.contributor.alternativeNameLee, Min Young-
dc.citation.volume280-
dc.citation.number7-
dc.citation.startPage5909-
dc.citation.endPage5916-
dc.identifier.bibliographicCitationJOURNAL OF BIOLOGICAL CHEMISTRY, Vol.280(7) : 5909-5916, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid40328-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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