Cited 127 times in
Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 박찬일 | - |
dc.date.accessioned | 2017-05-04T07:36:58Z | - |
dc.date.available | 2017-05-04T07:36:58Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147545 | - |
dc.description.abstract | The telomeric repeat-binding factor 1 (TRF1), TRF2, and the TRF1-interacting nuclear protein 2 (TIN2) are involved in telomere maintenance. We describe the regulation of expression of these genes along with their relationship to telomere length in hepatocarcinogenesis. The transcriptional expression of these genes, TRF1 protein, and telomere length was examined in 9 normal livers, 14 chronic hepatitis, 24 liver cirrhosis, 5 large regenerative nodules, 14 low-grade dysplastic nodules (DNs), 7 high-grade DNs, 10 DNs with hepatocellular carcinoma (HCC) foci, and 31 HCCs. The expression of TRF1, TRF2, TIN2 mRNA, and TRF1 protein was gradually increased according to the progression of hepatocarcinogenesis with a marked increase in high-grade DNs and DNs with HCC foci and a further increase in HCCs. There was a gradual shortening of telomere during hepatocarcinogenesis with a significant reduction in length in DNs. Most nodular lesions (52 of 67) had shorter telomeres than their adjacent chronic hepatitis or liver cirrhosis, and the telomere lengths were inversely correlated with the mRNA level of these genes (P </= 0.001). This was more evident in DNs and DNs with HCC foci. In conclusion, TRF1, TRF2, and TIN2 might be involved in multistep hepatocarcinogenesis by playing crucial roles in telomere shortening. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | DNA Primers | - |
dc.subject.MESH | DNA, Complementary/genetics | - |
dc.subject.MESH | Gene Expression Regulation* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Telomere/genetics* | - |
dc.subject.MESH | Telomere-Binding Proteins/genetics* | - |
dc.subject.MESH | Telomeric Repeat Binding Protein 1/genetics* | - |
dc.subject.MESH | Telomeric Repeat Binding Protein 2/genetics* | - |
dc.title | Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Bong-Kyeong Oh | - |
dc.contributor.googleauthor | Young-Joo Kim | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 10.1016/S0002-9440(10)62233-X | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01710 | - |
dc.relation.journalcode | J00100 | - |
dc.identifier.eissn | 1525-2191 | - |
dc.identifier.pmid | 15632001 | - |
dc.subject.keyword | 15632001 | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Chan Il | - |
dc.citation.volume | 166 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PATHOLOGY, Vol.166(1) : 73-80, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40320 | - |
dc.type.rims | ART | - |
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