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Selection of twenty-four highly informative SNP markers for human identification and paternity analysis in Koreans

Authors
 Hwan Young Lee  ;  Myung Jin Park  ;  Ji-Eun Yoo  ;  Ukhee Chung  ;  Gil-Ro Han  ;  Kyoung-Jin Shin 
Citation
 FORENSIC SCIENCE INTERNATIONAL, Vol.148(2~3) : 107-112, 2005 
Journal Title
FORENSIC SCIENCE INTERNATIONAL
ISSN
 0379-0738 
Issue Date
2005
MeSH
Asian Continental Ancestry Group/genetics* ; DNA Fingerprinting* ; DNA Primers ; Female ; Forensic Anthropology/methods ; Gene Frequency* ; Genetic Markers ; Genotype ; Humans ; Korea ; Male ; Paternity* ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide*
Keywords
Single nucleotide polymorphism ; Human identification ; Paternity analysis ; Koreans
Abstract
A number of DNA marker types suitable for human identification and parentage testing have been developed, of which single nucleotide polymorphisms (SNPs) merit attention as they are abundant, genetically stable, and amenable to high-throughput automated analysis. In this regard, 24 highly informative SNP markers representing each 22 autosome and both sex chromosomes were selected, and the allele and genotype frequencies of these SNPs were determined in a group composed of 30 unrelated Koreans. Based on frequency data from this group, the estimated probability of identity (PI) and probability of paternity exclusion (PE) with 22 autosomal SNP loci were 1.905 × 10−10 and 98.9%, respectively. The SNPs in this study offer a small but highly accurate database that will be an essential reference for SNP-based forensic application in the future.
Full Text
http://www.sciencedirect.com/science/article/pii/S0379073804003020
DOI
10.1016/j.forsciint.2004.04.073
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Chung, Uk Hee(정욱희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147538
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