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Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy

Authors
 Ukhee Chung  ;  Hwan Young Lee  ;  Ji-Eun Yoo  ;  Myung Jin Park  ;  Kyoung-Jin Shin 
Citation
 INTERNATIONAL JOURNAL OF LEGAL MEDICINE, Vol.119(1) : 50-53, 2005 
Journal Title
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
ISSN
 0937-9827 
Issue Date
2005
MeSH
Asian Continental Ancestry Group/genetics* ; Complementarity Determining Regions ; DNA Fingerprinting/methods* ; DNA Primers ; DNA, Mitochondrial/genetics* ; Dinucleotide Repeats* ; Gene Frequency ; Genetic Variation ; Genetics, Population* ; Genotype ; Humans ; Korea ; Polymerase Chain Reaction/methods ; Sequence Analysis, DNA
Keywords
Mitochondrial DNA ; CA dinucleotide repeats ; Length polymorphism ; Length heteroplasmy ; Koreans
Abstract
The mitochondrial DNA HV3 region contains CA dinucleotide repeats which display length polymorphism. To analyze this for forensic purposes, we designed a fluorescence-labelled PCR primer set for short amplification products and carried out genotyping by using capillary electrophoresis. A total of 4 alleles with 4–7 repeat units were observed and the genetic diversity was estimated to be 0.5120 in 500 unrelated Koreans. Interestingly, three individuals showed two or three length variants, i.e. length heteroplasmy.
Full Text
http://link.springer.com/article/10.1007%2Fs00414-004-0487-7
DOI
10.1007/s00414-004-0487-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Chung, Uk Hee(정욱희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147527
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