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소아 및 청소년 비만증에서 인슐린 저항성의 성별 차이

Other Titles
 Gender Difference of Insulin Resistance in Obese Children and Adolescents 
 김덕희  ;  윤지현  ;  김호성  ;  김동기  ;  정미영 
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.10(1) : 84-89, 2005 
Journal Title
Journal of Korean Society of Pediatric Endocrinology(대한소아내분비학회지)
Issue Date
insulin resistence ; obesity ; children ; adolescents ; adiponectin ; HOMA-IR
insulin resistence ; obesity ; children ; adolescents ; adiponectin ; HOMA-IR
Purpose: It is known that insulin resistance is important because it may precede the development of Diabetes Mellitus. We evaluated the gender difference of insulin resistance in obese children & adolescents.

Methods: 92 obese children and 187 adolescents (age:5-16 y, >95th percentile of the body mass index [BMI] for age and sex) were included in this study. The abdominal fat, abdominal circumference, and intraabdominal fat depth (IAFD), plasma fasting insulin, leptin, adiponectin, lipid profiles and high sensitive-C reactive protein (hs-CRP) were measured, and a two-hour oral glucose tolerance test with insulin measurement were performed.

Results: The plasma total cholesterol, leptin, fasting insulin & HOMA-IR levels of obese females were higher than those of obese males. The sex, waist circumference, IAFD & adiponectin levels were strongly correlated with HOMA-IR by multiple linear regression analysis (P<0.05).

Conclusion: Adolescent females may have specific fat distribution and were expressed to have higher leptin and relatively lower adiponectin concentration compared to adolescent males, developing higher insulin resistance, even though having lesser abdominal fat and waist size. Further investigation is required to verify the gender difference of insulin resistance in obese children and adolescents.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Dong Ki(김동기)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Cheong, My Young(정미영)
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