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Effects of β-glucan on proliferation and migration of fibroblasts

Authors
 Son Hyun Joo  ;  Bae Hyun Chul  ;  Kim Hyun Jeong  ;  Lee Dong Hee  ;  Han Dong-Wook  ;  Park Jong-Chul 
Citation
 CURRENT APPLIED PHYSICS, Vol.5(5) : 468-471, 2005 
Journal Title
 CURRENT APPLIED PHYSICS 
ISSN
 1567-1739 
Issue Date
2005
MeSH
β-Glucan ; Wound healing ; Fibroblast ; Migration ; Proliferation
Keywords
β-Glucan ; Wound healing ; Fibroblast ; Migration ; Proliferation
Abstract
β-Glucans, originated from the outer cell wall of fungi, are shown to have immune stimulatory activity, especially to enhance wound healing. In the wound healing processes, the migration and proliferation of fibroblasts are essential. Actually fetal and neonatal wounds heal without scar because the migration of those dermal fibroblasts is faster than that of adult fibroblasts. Furthermore, it has been reported that human dermal fibroblasts express receptors for β-glucans like macrophages. In this study, the direct effects of β-glucans on the proliferation and migration of L-929 fibroblasts were examined in vitro. β-Glucan treatment to the L-929 cells with 0.5 or 5 mg/ml resulted in a significant (p < 0.05) dose-dependant increase in cell proliferation. However, the migration assay using a self-designed cell tracking system showed that there was no significant difference in the migration speed between the glucan-treated and non-treated cells. These results suggest that β-glucans can enhance directly fibroblast proliferation in vitro, but not affect fibroblast migration.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173905000179
DOI
10.1016/j.cap.2005.01.011
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Jung(김현정)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Bae, Hyun Chul(배현철)
Son, Hyun Joo(손현주)
Lee, Dong Hee(이동희)
Han, Dong Wook(한동욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147494
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