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당뇨병성 신증 환자의 좌심실비대와 안지오텐신 전환효소 유전자 다형성과의 관계

Other Titles
 Association between Left Ventricular Hypertrophy (LVH) and Angiotensin Converting Enzyme (ACE) Gene Polymorphism in Diabetic Nephropathy Patients 
 이태희  ;  박형천  ;  남지선  ;  노태웅  ;  이재성  ;  백승석  ;  강신욱  ;  최규헌  ;  이호영  ;  한대석  ;  하성규 
 Korean Journal of Nephrology (대한신장학회지), Vol.24(1) : 90-99, 2005 
Journal Title
 Korean Journal of Nephrology (대한신장학회지) 
Issue Date
BACKGROUND: Left ventricular hypertrophy (LVH) is an important risk factor of cardiovascular disease in diabetic nephropathy patients. Renin-angiotensin system has an independent role as a neurohormonal factor in promoting cardiac growth and remodeling. Genetic and environmental factors also influence the pathogenesis of LVH. The association of LVH progression and angiotensin converting enzyme (ACE) gene polymorphism is well known, especially in ACE DD genotype. But there is some controversy between LVH and ACE gene polymorphism. So, we evaluated the prevalence and patterns of LVH and analyzed the associated factors including ACE polymorphism in diabetic nephropathy patients. METHODS: One hundred and eighty one type 2 diabetic patients with overt proteinuria were recruited in the study. ACE genotyping and echocardiogram were performed to observe the association between LVH and ACE polymorphism. RESULTS: The prevalence of LVH was 141 out of 181 (77.9%) patients (concentric, 35.9% and eccentric, 42.0%, each). Patterns of LVH, left ventricular mass (LVM), and left ventricular mass index (LVMI) showed no differences among the three genotypes. But, LVMI was higher in DD genotype group than in II group in men (171.2 vs. 144.8, p=0.028). On the other hand, in women, there were no differences of clinical and echocardiographic variables among three genotypes. LVM and LVMI were negatively correlated with hemoglobin level in all patients. CONCLUSION: The results suggest that ACE DD genotype is associated with LVH in male patients with diabetic nephropathy, but not in female patients. Determining whether or not the gender influences LVH in the diabetic nephropathy patients will require further studies.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
박형천(Park, Hyeong Cheon) ORCID logo https://orcid.org/0000-0002-1550-0812
이태희(Lee, Tae Hee)
이호영(Lee, Ho Yung)
최규헌(Choi, Kyu Hun) ORCID logo https://orcid.org/0000-0003-0095-9011
하성규(Ha, Sung Kyu)
한대석(Han, Dae Suk)
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