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비소세포성 폐암 세포주에서 farnesyl transferase inhibitor SCH66336과 인슐린양 성장 인자 결합 단백-3의 병용처리에 의한 세포고사 상승 작용

Other Titles
 Synergism Induced by Combination of Farnesyl Transferase Inhibitor SCH66336 and Insulin Like-Growth Factor Binding Protein-3 in apoptosis of Non-Small Cell Lung Cancer Cell Lines 
Authors
 김 영  ;  김세규  ;  김형중  ;  장 준  ;  안철민  ;  김성규  ;  장윤수 
Citation
 Tuberculosis and Respiratory Diseases, Vol.58(2) : 120-128, 2005 
Journal Title
 Tuberculosis and Respiratory Diseases 
ISSN
 1738-3536 
Issue Date
2005
Abstract
Background : Insulin-like growth factor binding protein (IGFBP)-3 regulates non-small cell lung cancer(NSCLC) cell proliferation in vitro and in vivo by inhibiting IGF-mediated signaling pathways. To have better strategies for the treatment of lung cancer, we analyzed the combining effects of adenovirus expressing IGFBP-3 (Ad5CMV-BP3) and SCH66336, a farnesyl transferase inhibitor (FTI) designed to block Ras-mediated proliferative signaling pathways. Methods : To measure the combining effects of Ad5CMV-BP3 and SCH66336 on the proliferation of NSCLC cells,human NSCLC cell lines (H1299, H596, A549, H460, and H358), SCH66336, recombinant adenovirus expressing IGFBP-3 (Ad5CMV-BP3) and athymic nude mice were used in these experiments. Results : The combination of Ad5CMV-BP3 and SCH66336 produced a synergistic enhancement in antiproliferative effects over a range of clinically achievable concentrations in a variety of NSCLC cell lines. Furthermore, we observed a significant reduction in growth of NSCLC xenograft induced in athymic nude mice. Conclusion : In conclusion, this study demonstrated for the first time that the FTI SCH66336 synergizes with IGFBP-3 and enhances its apoptotic activity in NSCLC cells in vitro and in vivo. The combined treatment of Ad5CMV-BP3 and SCH66336 raises the possibility of using this regimen in clinic for the treatment of NSCLC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young(김영)
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Ahn, Chul Min(안철민)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147408
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