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산발성 난소암에서의 BRCA1과 BRCA2의 배선 유전자 돌연변이와 유전자다형성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재욱 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 김현기 | - |
dc.date.accessioned | 2017-05-04T07:30:56Z | - |
dc.date.available | 2017-05-04T07:30:56Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5628 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147398 | - |
dc.description.abstract | Objective: Mutations in the BRCA1 and BRCA2 genes predispose women to ovarian and/or breast cancer. The purposes of this study were firstly to investigate the presence of BRCA1 and BRCA2 mutations in women with non-hereditary ovarian cancer and secondly to evaluate the relationship between ovarian cancer susceptibility gene polymorphism and clinicopathological features. Methods: We studied 37 women who received a diagnosis of sporadic ovarian epithelial cancer and were treated at our hospital between August 2002 and March 2004. Genomic DNA was analyzed for BRCA mutations using PCR-DHPLC-sequencing method. And we examined the relationship between ovarian cancer susceptibility gene polymorphism and clinicopathological features using a high- throughput SNP scoring methods. Results: Most mutations of BRCA1 and BRCA2 associated with ovarian and/or breast cancer resulted in truncated proteins. We found one frameshift mutation in BRCA1 (3746insA) led to premature termination. She has no family history of breast and ovarian cancer. There was no relationship between ovarian cancer susceptibility gene polymorphisms and clinicopathological features. Conclusion: Our results were consistent with the concept that there was a limited role of BRCA1 and BRCA2 mutations in ovarian carcinogenesis in Korean population and polymorphisms of some selected ovarian cancer susceptibility genes were not associated with the clinicopathological phenotypes of ovarian cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1466~1475 | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | BRCA1 | - |
dc.subject.MESH | BRCA2 | - |
dc.subject.MESH | Germline mutation | - |
dc.subject.MESH | Sporadic ovarian carcinoma | - |
dc.subject.MESH | Polymorphism | - |
dc.title | 산발성 난소암에서의 BRCA1과 BRCA2의 배선 유전자 돌연변이와 유전자다형성 | - |
dc.title.alternative | Germline Mutations and polymorphisms of BRCA1 and BRCA2 in Sporadic Ovarian Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 남은지 | - |
dc.contributor.googleauthor | 김영태 | - |
dc.contributor.googleauthor | 김성훈 | - |
dc.contributor.googleauthor | 김재훈 | - |
dc.contributor.googleauthor | 구자성 | - |
dc.contributor.googleauthor | 김상운 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.googleauthor | 김현기 | - |
dc.identifier.doi | OAK-2005-02703 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00866 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A01108 | - |
dc.relation.journalcode | J02076 | - |
dc.relation.journalsince | 1958~2004 | - |
dc.relation.journalafter | 2005~ Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.subject.keyword | BRCA1 | - |
dc.subject.keyword | BRCA2 | - |
dc.subject.keyword | Germline mutation | - |
dc.subject.keyword | Sporadic ovarian carcinoma | - |
dc.subject.keyword | Polymorphism | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Wook | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.citation.volume | 48 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1466 | - |
dc.citation.endPage | 1475 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(6) : 1466-1475, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48569 | - |
dc.type.rims | ART | - |
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