Cited 153 times in
Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea
DC Field | Value | Language |
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dc.contributor.author | 송재석 | - |
dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2017-05-04T07:28:44Z | - |
dc.date.available | 2017-05-04T07:28:44Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147347 | - |
dc.description.abstract | We investigated an outbreak of Acinetobacter baumannii in an intensive care unit and in the surgery, medicine, neurology, and urology wards of the Kosin University Gospel Hospital in Busan, Korea. The outbreak involved 36 cases of infection by A. baumannii producing the OXA-23 β-lactamase over an 8-month period and was caused by a single pulsed-field gel electrophoresis clone. The epidemic isolates were characterized by a modified cloverleaf synergy test. Isoelectric focusing of crude bacterial extracts detected one nitrocefin-positive band with a pI value of 6.65. PCR amplification and characterization of the amplicons by direct sequencing indicated that the epidemic isolates carried a blaOXA-23 determinant. The epidemic isolates were characterized by a multidrug resistance phenotype that remained unchanged over the outbreak, including penicillins, cephamycins, extended-spectrum cephalosporins, carbapenems, monobactams, and aminoglycosides. This study shows that the blaOXA-23 resistance determinant may become an emerging therapeutic problem. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2241~2245 | - |
dc.language | English | - |
dc.publisher | American Society for Microbiology | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MICROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acinetobacter baumannii/classification | - |
dc.subject.MESH | Acinetobacter baumannii/enzymology | - |
dc.subject.MESH | Acinetobacter baumannii/genetics* | - |
dc.subject.MESH | Acinetobacter baumannii/isolation & purification* | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Conjugation, Genetic | - |
dc.subject.MESH | Cross Infection/microbiology* | - |
dc.subject.MESH | DNA Primers | - |
dc.subject.MESH | Drug Resistance, Microbial | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imipenem/pharmacology* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | beta-Lactamases/genetics* | - |
dc.title | Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Byung-Chan Jeon | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | Su Bong Kwon | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Dongeun Young | - |
dc.contributor.googleauthor | Jung Hun Lee | - |
dc.contributor.googleauthor | Jae Seok Song | - |
dc.contributor.googleauthor | Sang Hee Lee | - |
dc.identifier.doi | 10.1128/JCM.43.5.2241-2245.2005 | - |
dc.contributor.localId | A02052 | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J01325 | - |
dc.identifier.eissn | 1098-660X | - |
dc.identifier.pmid | 15872249 | - |
dc.subject.keyword | 15872249 | - |
dc.contributor.alternativeName | Song, Jae Seok | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2241 | - |
dc.citation.endPage | 2245 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MICROBIOLOGY, Vol.43(5) : 2241-2245, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48519 | - |
dc.type.rims | ART | - |
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