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Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea

Authors
 Byung-Chan Jeon  ;  Seok Hoon Jeong  ;  Il Kwon Bae  ;  Su Bong Kwon  ;  Kyungwon Lee  ;  Dongeun Young  ;  Jung Hun Lee  ;  Jae Seok Song  ;  Sang Hee Lee 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.43(5) : 2241-2245, 2005 
Journal Title
 JOURNAL OF CLINICAL MICROBIOLOGY 
ISSN
 0095-1137 
Issue Date
2005
MeSH
Acinetobacter baumannii/classification ; Acinetobacter baumannii/enzymology ; Acinetobacter baumannii/genetics* ; Acinetobacter baumannii/isolation & purification* ; Base Sequence ; Conjugation, Genetic ; Cross Infection/microbiology* ; DNA Primers ; Drug Resistance, Microbial ; Genotype ; Humans ; Imipenem/pharmacology* ; Korea ; Microbial Sensitivity Tests ; beta-Lactamases/genetics*
Keywords
15872249
Abstract
We investigated an outbreak of Acinetobacter baumannii in an intensive care unit and in the surgery, medicine, neurology, and urology wards of the Kosin University Gospel Hospital in Busan, Korea. The outbreak involved 36 cases of infection by A. baumannii producing the OXA-23 β-lactamase over an 8-month period and was caused by a single pulsed-field gel electrophoresis clone. The epidemic isolates were characterized by a modified cloverleaf synergy test. Isoelectric focusing of crude bacterial extracts detected one nitrocefin-positive band with a pI value of 6.65. PCR amplification and characterization of the amplicons by direct sequencing indicated that the epidemic isolates carried a blaOXA-23 determinant. The epidemic isolates were characterized by a multidrug resistance phenotype that remained unchanged over the outbreak, including penicillins, cephamycins, extended-spectrum cephalosporins, carbapenems, monobactams, and aminoglycosides. This study shows that the blaOXA-23 resistance determinant may become an emerging therapeutic problem.
Files in This Item:
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DOI
10.1128/JCM.43.5.2241-2245.2005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Seok(송재석)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147347
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