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초음파가 표피 투과 장벽과 표피 지질 합성에 미치는 효과
DC Field | Value | Language |
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dc.contributor.author | 이승헌 | - |
dc.date.accessioned | 2017-05-04T07:28:43Z | - |
dc.date.available | 2017-05-04T07:28:43Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147346 | - |
dc.description.abstract | Background: Abrogation of the epidermal permeability barrier results in an increased lipid synthesis and lipid synthetic enzymes. Recent studies have shown that ultrasound can induce changes in the epidermal calcium gradient that increase lamellar body secretion without increasing transepidermal water loss (TEWL). Objective: We undertook this study to identify whether ultrasound can stimulate lipids synthetic enzymes and lipids synthesis. Methods: Ultrasounds were applied to the skin of hairless mice, and we then quantified lipid synthesis, real time RT-PCR to measure mRNA activities of lipid synthetic enzymes and TEWL. We also performed RuO4 post fixation and calcium ion capture cytochemistry. Results: There were no significant changes of TEWL before and after ultrasound treatment. Calcium in upper epidermis decreased and that in lower epidermis increased after treatment of ultrasound and some recovery of epidermal calcium gradient after 6 hours. In RuO4 post fixation, lacuna dilatation, partial distension of intercorneocyte space, loss of multilamellar structures and increased lamellar body secretion were observed in the epidermis of the ultrasound treated hairless mice. The mRNA levels of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase, serine palmitoyl transferase (SPT), fatty acid synthase (FAS) and lipid synthesis were increased in the epidermis of the ultrasound treated hairless mice. Conclusion: Ultrasound can increase mRNA of lipids synthetic enzymes and lipids synthesis without increasing TEWL by changing calcium ion gradients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 619~629 | - |
dc.language | Korean | - |
dc.publisher | 대한피부과학회 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Epidermal Permeability Barrier | - |
dc.subject.MESH | Ultrasound | - |
dc.subject.MESH | Epidermal Lipid Synthesis | - |
dc.subject.MESH | Lipid Synthetic enzymes | - |
dc.title | 초음파가 표피 투과 장벽과 표피 지질 합성에 미치는 효과 | - |
dc.title.alternative | The Effect of Ultrasound on Epidermal Permeability Barrier and Lipid Synthesis | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | 조남준 | - |
dc.contributor.googleauthor | 정세규 | - |
dc.contributor.googleauthor | 전정은 | - |
dc.contributor.googleauthor | 최기주 | - |
dc.contributor.googleauthor | 박석종 | - |
dc.contributor.googleauthor | 안호정 | - |
dc.contributor.googleauthor | 안성구 | - |
dc.contributor.googleauthor | 이승헌 | - |
dc.identifier.doi | OAK-2005-02539 | - |
dc.contributor.localId | A02931 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | Epidermal Permeability Barrier | - |
dc.subject.keyword | Ultrasound | - |
dc.subject.keyword | Epidermal Lipid Synthesis | - |
dc.subject.keyword | Lipid Synthetic enzymes | - |
dc.contributor.alternativeName | Lee, Seung Hun | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 629 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.43(5) : 619-629, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48518 | - |
dc.type.rims | ART | - |
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