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Genetic aberrance of sporadic MEN 2A component tumours: analysis of RET

DC Field Value Language
dc.contributor.author강숙희-
dc.contributor.author박정수-
dc.contributor.author정웅윤-
dc.contributor.author조남훈-
dc.date.accessioned2017-05-04T07:27:46Z-
dc.date.available2017-05-04T07:27:46Z-
dc.date.issued2005-
dc.identifier.issn0031-3025-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147323-
dc.description.abstractAIM: The molecular pathogenesis of familial multiple endocrine neoplasia (MEN) type 2 (parathyroid adenoma with medullary thyroid carcinoma and adrenal pheochromocytoma) is associated with a germ-line mutation in the RET proto-oncogene. We undertook this study to clarify the relationship between the tumorigenesis of apparently sporadic MEN type 2 component endocrine tumours and RET mutations. METHODS: Direct sequencing for RET exon 10, 11, 12, 13, 14, 15 and 16 and immunohistochemistry for RET monoclonal antibody were performed on the archival tissues of 84 cases of sporadic endocrine tumours, including 22 medullary thyroid carcinomas (MTCs), 35 adrenal pheochromocytomas (APCs), 18 paragangliomas (PGs), and nine parathyroid adenomas (PTAs). RESULTS: PCR-based direct sequencing revealed somatic point missense mutation within 22.7% of exon 13 of the RET proto-oncogene (four cases of E768D, one case of S7781) in MTCs. No RET genotype and morphological association was observed in MTCs or APCs. APCs revealed significantly lower levels of immunoexpression of RET, even versus PGs. CONCLUSIONS: The genetic mutation in RET is relatively low in incidence, and likely to play an insignificant role in the molecular pathogenesis of sporadic MTC. The molecular bases of PG and APC seem to be different despite their embryological and histological similarities.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfPATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenal Gland Neoplasms/genetics-
dc.subject.MESHAdrenal Gland Neoplasms/metabolism-
dc.subject.MESHAdult-
dc.subject.MESHBase Sequence-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMultiple Endocrine Neoplasia/genetics*-
dc.subject.MESHMultiple Endocrine Neoplasia/metabolism-
dc.subject.MESHOncogene Proteins/genetics*-
dc.subject.MESHOncogene Proteins/metabolism-
dc.subject.MESHParaganglioma/genetics-
dc.subject.MESHParaganglioma/metabolism-
dc.subject.MESHParathyroid Neoplasms/genetics-
dc.subject.MESHParathyroid Neoplasms/metabolism-
dc.subject.MESHPheochromocytoma/genetics-
dc.subject.MESHPheochromocytoma/metabolism-
dc.subject.MESHPoint Mutation-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHProto-Oncogene Proteins c-ret-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/genetics*-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/metabolism-
dc.subject.MESHThyroid Neoplasms/genetics-
dc.subject.MESHThyroid Neoplasms/metabolism-
dc.titleGenetic aberrance of sporadic MEN 2A component tumours: analysis of RET-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorNAM HOON CHO-
dc.contributor.googleauthorHYUN WOO LEE-
dc.contributor.googleauthorSHIN YOUNG LIM-
dc.contributor.googleauthorSUKI KANG-
dc.contributor.googleauthorWUNG YUN JUNG-
dc.contributor.googleauthorCHUNG SU PARK-
dc.identifier.doiOAK-2005-02473-
dc.contributor.localIdA00044-
dc.contributor.localIdA01646-
dc.contributor.localIdA03674-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ02471-
dc.identifier.eissn1465-3931-
dc.identifier.pmid15875728-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01268031-200537010-00002&LSLINK=80&D=ovft-
dc.subject.keyword15875728-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.citation.volume37-
dc.citation.number1-
dc.citation.startPage10-
dc.citation.endPage13-
dc.identifier.bibliographicCitationPATHOLOGY, Vol.37(1) : 10-13, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid48495-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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